Loh Marie, Koh King Xin, Yeo Boon Huat, Song Chun Meng, Chia Kee Seng, Zhu Feng, Yeoh Khay Guan, Hill Jeffrey, Iacopetta Barry, Soong Richie
Cancer Science Institute of Singapore, National University of Singapore, 28 Medical Drive, Center of Life Science Level 2, Singapore 117456, Singapore.
Eur J Cancer. 2009 Sep;45(14):2562-8. doi: 10.1016/j.ejca.2009.03.017. Epub 2009 Apr 15.
The goal of this study was to consolidate information on genetic risk factors for gastric cancer. An additional aim was to investigate the influence of race on these genetic risk associations. Relevant studies were identified from PubMed and references of retrieved articles. Meta-analysis techniques were used to summarise associations between genetic polymorphisms and gastric cancer. A total of 203 relevant studies were identified, assessing 225 polymorphisms across 95 genes. Subgroup analysis indicated that Chinese, Japanese and Korean data were consistent and could be pooled. However, 6 of 13 polymorphisms (ACE I/D, CCND1 870G>A, CDH1 -160C>A, IL1B -511C>T, IL4 -590C>T, IL10 -592A>C) displayed conflicting effects between Asian and Caucasian populations, three of which (ACE I/D, CCND1 870G>A, IL1B -511C>T) had significantly different odds ratios between the two racial groups. In total, 37 polymorphisms across 27 genes were found to be significantly associated with gastric cancer in Asians, and 12 polymorphisms across 11 genes in Caucasians. Consolidated panels of polymorphisms associated with gastric cancer risk were identified in Asians and Caucasians. The results caution against the assumption that genetic risk factors are consistent between races.
本研究的目的是整合有关胃癌遗传风险因素的信息。另一个目的是调查种族对这些遗传风险关联的影响。从PubMed及检索文章的参考文献中识别相关研究。采用荟萃分析技术总结基因多态性与胃癌之间的关联。共识别出203项相关研究，评估了95个基因中的225种多态性。亚组分析表明，中国、日本和韩国的数据一致，可以合并。然而，13种多态性中的6种（ACE I/D、CCND1 870G>A、CDH1 -160C>A、IL1B -511C>T、IL4 -590C>T、IL10 -592A>C）在亚洲人和白种人群体中显示出相互矛盾的效应，其中三种（ACE I/D、CCND1 870G>A、IL1B -511C>T）在两个种族群体之间的优势比有显著差异。总共发现，27个基因中的37种多态性与亚洲人的胃癌显著相关，11个基因中的12种多态性与白种人的胃癌显著相关。在亚洲人和白种人中确定了与胃癌风险相关的多态性综合组。结果警示不要假定种族之间的遗传风险因素是一致的。
