Department of Medicinal Chemistry, North East Institute of Science and Technology, Jorhat, Assam, 785 006, India.
Mol Divers. 2010 Nov;14(4):841-6. doi: 10.1007/s11030-009-9214-0. Epub 2009 Dec 5.
An environmentally friendly and highly efficient procedure for the preparation of quinolines and fused polycyclic quinolines has been developed by a simple Friedlander annulation reaction of 2-aminoaryl ketone with carbonyl compounds in presence of zinc triflate under microwave irradiation and solvent-free conditions. The reaction also proceeds effectively when In(OTf)(3) was used in lieu of Zn(OTf)(2) as the catalyst. The catalyst can be recovered after the reaction and reused efficiently in subsequent runs.
一种环境友好且高效的制备喹啉和稠合多环喹啉的方法，是通过 2-芳基氨基酮与羰基化合物在三氟甲磺酸锌存在下，于微波辐射和无溶剂条件下进行简单的 Friedlander 环化反应而开发的。当用三氟化铟（In(OTf)(3)）代替 Zn(OTf)(2)作为催化剂时，该反应也能有效地进行。反应后催化剂可以回收，并在后续反应中有效地重复使用。
