一种温和且高效的喹啉一步合成法。
A mild and efficient one-step synthesis of quinolines.
作者信息
McNaughton Brian R, Miller Benjamin L
机构信息
Department of Dermatology, The Center for Future Health, University of Rochester, Rochester, New York 14642, USA.
出版信息
Org Lett. 2003 Nov 13;5(23):4257-9. doi: 10.1021/ol035333q.
PMID:14601974
Abstract
[reaction: see text] The Friedländer synthesis of quinolines is an extensively employed protocol, yielding the desired heterocycle in a two-step reduction-condensation sequence. We have developed a mild, efficient, high-yielding single-step variant of this methodology, which employs SnCl(2) and ZnCl(2) to effect the reaction.
摘要
[反应：见正文] 喹啉的弗里德兰德合成是一种广泛应用的方法，通过两步还原-缩合序列得到所需的杂环。我们已经开发出了这种方法的一种温和、高效、高产率的单步变体，该变体使用SnCl₂和ZnCl₂来实现反应。
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