Competence Center skintegral, Department of Dermatology, University Medical Center Freiburg, Hauptstr. 7, D-79104 Freiburg, Germany.
Phytother Res. 2010 Jul;24(7):1033-6. doi: 10.1002/ptr.3069.
Reseda luteola L. has been used as a dye due to its high luteolin content since ancient times. However, no pharmacological studies have been performed with Reseda extracts so far. Here, we have assessed antiproliferative and apoptosis-inducing effects of the Reseda extract RF-40. It contains 40% flavonoids, primarily luteolin, but also luteolin-7-O-glucoside and apigenin. RF-40 and the isolated flavonoids dose-dependently inhibited cell proliferation and induced apoptotic oligonucleosomes in PHA-stimulated peripheral blood mononuclar cells. These effects were not due to cytotoxicity as shown with a luminometric ATP assay. Dose-response curves of RF-40 and the isolated flavonoids were similar, with luteolin being the most effective isolated flavonoid. Comparison of RF-40 to its major flavonoids revealed that the pharmacological effects of the extract can mostly be attributed to luteolin. We conclude that Reseda extract is an interesting raw material not only for dyeing purposes but also for further pharmacological investigation.
自古以来，由于其含有较高的木犀草素，瑞香狼毒 L. 就被用作染料。然而，迄今为止，尚未对瑞香狼毒提取物进行药理学研究。在这里，我们评估了瑞香狼毒提取物 RF-40 的抗增殖和诱导细胞凋亡作用。它含有 40%的类黄酮，主要是木犀草素，但也含有木犀草素-7-O-葡萄糖苷和芹菜素。RF-40 和分离的类黄酮以剂量依赖的方式抑制 PHA 刺激的外周血单核细胞增殖，并诱导凋亡小体。这些作用不是由于细胞毒性所致，如发光 ATP 测定所示。RF-40 和分离的类黄酮的剂量反应曲线相似，木犀草素是最有效的分离类黄酮。将 RF-40 与其主要类黄酮进行比较表明，提取物的药理作用主要归因于木犀草素。我们得出结论，瑞香狼毒提取物不仅是一种有趣的染料原料，而且也是进一步药理学研究的有价值原料。
