Collum R G, Clayton D F, Alt F W
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Mol Cell Biol. 1991 Mar;11(3):1770-6. doi: 10.1128/mcb.11.3.1770-1776.1991.
We found that the canary N-myc gene is highly related to mammalian N-myc genes in both the protein-coding region and the long 3' untranslated region. Examined coding regions of the canary c-myc gene were also highly related to their mammalian counterparts, but in contrast to N-myc, the canary and mammalian c-myc genes were quite divergent in their 3' untranslated regions. We readily detected N-myc and c-myc expression in the adult canary brain and found N-myc expression both at sites of proliferating neuronal precursors and in mature neurons.
我们发现，金丝雀N-myc基因在蛋白质编码区和长3'非翻译区都与哺乳动物的N-myc基因高度相关。所检测的金丝雀c-myc基因的编码区也与其哺乳动物对应物高度相关，但与N-myc不同的是，金丝雀和哺乳动物的c-myc基因在其3'非翻译区有很大差异。我们很容易在成年金丝雀大脑中检测到N-myc和c-myc的表达，并发现N-myc在增殖的神经元前体细胞部位和成熟神经元中均有表达。
