Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Sun Yat-sen University, 56 Lingyuanxi Road, Guangzhou, 510055, China.
Arch Oral Biol. 2010 Jan;55(1):15-20. doi: 10.1016/j.archoralbio.2009.11.006. Epub 2009 Dec 3.
The purpose of the present study was to investigate the electrolyte alterations of submandibular/sublingual saliva in submandibular sialolithiasis patients compared with saliva from healthy controls.
Submandibular/sublingual saliva was collected from 10 submandibular sialolithiasis patients and from 10 sex- and age-matched healthy controls. Ion chromatography was performed to determine the concentrations of inorganic cations (potassium, calcium, magnesium, and sodium), inorganic anions (chloride, phosphate, nitrate, and sulphate) and organic anions (thiocyanate, lactate, acetate, and citrate).
The calcium concentration was significantly higher in sialolithiasis patients than in controls (P<0.05). In contrast, the levels of magnesium and citrate in the saliva of sialolithiasis patients were significantly reduced compared to the values obtained in controls (P<0.05). No significant differences were detected among other ions.
Our findings indicate that saliva electrolyte composition of sialolithiasis patients is substantially altered with respect to crystallisation mechanisms. Increased calcium ion as a crystallisation substance and decreased magnesium and citrate ions as crystallisation inhibitors may be involved in the etiopathology of calculi formation.
本研究旨在比较下颌下唾液与健康对照组唾液的电解质变化，以探讨下颌下唾液在颌下唾液结石病患者中的作用。
收集 10 例颌下唾液结石病患者和 10 例年龄和性别匹配的健康对照组的下颌下/舌下唾液。采用离子色谱法测定无机阳离子（钾、钙、镁、钠）、无机阴离子（氯、磷、硝酸盐、硫酸盐）和有机阴离子（硫氰酸盐、乳酸盐、醋酸盐、柠檬酸盐）的浓度。
结石病患者的钙浓度明显高于对照组（P<0.05）。相比之下，结石病患者唾液中的镁和柠檬酸盐水平明显低于对照组（P<0.05）。其他离子之间无显著差异。
我们的研究结果表明，颌下唾液结石病患者的唾液电解质组成发生了实质性变化，这与结晶机制有关。作为结晶物质的钙离子增加，以及作为结晶抑制剂的镁和柠檬酸盐离子减少，可能参与了结石形成的病因。
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