PG Department of Chemistry, Karnatak University, Dharwad, Karnataka, India.
J Enzyme Inhib Med Chem. 2010 Jun;25(3):430-9. doi: 10.3109/14756360903257876.
A series of metal complexes of cobalt(II), nickel(II), and copper(II) have been synthesized with newly derived biologically active ligands. These ligands were synthesized by the condensation of 2-amino-4-phenyl-1,3-thiazole with 8-formyl-7-hydroxy- 4-methylcoumarin. The probable structure of the complexes has been proposed on the basis of analytical and spectroscopic data (IR, UV-Vis, ESR, FAB-mass, and thermoanalytical). Electrochemical study of the complexes is also reported. Elemental analysis of the complexes confined them to stoichiometry of the type ML(2).2H(2)O [M = Co(II), Ni(II), and Cu(II)]. The Schiff base and its metal(II) complexes have been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Staphylococcus pyogenes, and Pseudomonas aeruginosa) and antifungal activities (Aspergillus niger, Aspergillus flavus, and Cladosporium) by the MIC method. The brine shrimp bioassay was carried out to study their in vitro cytotoxic properties, and also the Schiff base and its metal(II) complexes have been studied for DNA cleavage.
已经用新合成的具有生物活性的配体合成了一系列钴(II)、镍(II)和铜(II)的金属配合物。这些配体是通过 2-氨基-4-苯基-1,3-噻唑与 8-甲酰基-7-羟基-4-甲基香豆素缩合而成的。根据分析和光谱数据（IR、UV-Vis、ESR、FAB-质量和热分析）提出了配合物的可能结构。还报告了配合物的电化学研究。配合物的元素分析将它们限制在 ML(2).2H(2)O [M = Co(II)、Ni(II)和 Cu(II)]的化学计量比。采用 MIC 法测定了希夫碱及其金属（II）配合物的抑菌（大肠杆菌、金黄色葡萄球菌、化脓性链球菌和铜绿假单胞菌）和抗真菌活性（黑曲霉、黄曲霉和枝孢菌）。进行了卤虫生物测定以研究其体外细胞毒性，并研究了希夫碱及其金属（II）配合物的 DNA 切割。
