Department of Medicine, University of Toronto, Canadian Blood Services, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada.
Transfus Med Rev. 2010 Jan;24 Suppl 1:S28-50. doi: 10.1016/j.tmrv.2009.09.011.
The standard treatment for patients with primary antibody deficiency is immunoglobulin (IG), but the care of these patients is complex. These guidelines, initiated by the Canadian Blood Services and the National Advisory Committee on Blood and Blood Products, have been developed to facilitate and standardize the care of these patients by the various physician specialties that are responsible for their care. A panel of national expert immunologists and methodologists developed salient clinical questions; and a systematic, expert, and bibliography literature search up to July 2008 was conducted. One thousand eighty-seven citations were retrieved, and 102 reports were used in the preparation of this guideline. The recommendations provide guidance (1) on the complexity of the treatment of these patients; (2) the established benefits of IG on morbidity and mortality; (3) dosage, routes of administration, and management of reactions; (4) the various IG formulations available; (5) vaccination of these patients; and (6) research priorities.
原发性抗体缺陷患者的标准治疗方法是免疫球蛋白（IG），但这些患者的治疗较为复杂。本指南由加拿大血液服务中心和国家血液和血液制品咨询委员会发起制定，旨在促进和规范各负责患者治疗的专科医生对这些患者的治疗。一个国家专家免疫学家和方法学家小组提出了突出的临床问题；并对截至 2008 年 7 月的相关文献进行了系统的、专家的、以及文献检索。共检索到 1087 条引文，并在本指南的编写中使用了 102 份报告。这些建议提供了指导（1）治疗这些患者的复杂性；（2）IG 对发病率和死亡率的确定益处；（3）剂量、给药途径和反应管理；（4）可用的各种 IG 制剂；（5）这些患者的疫苗接种；以及（6）研究重点。
