Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
Atherosclerosis. 2010 Mar;209(1):197-200. doi: 10.1016/j.atherosclerosis.2009.08.027. Epub 2009 Aug 21.
The relationship between coronary endothelial function and coronary calcification is not well established.
Forty-six patients 17 men [37%]; age, 47.4+/-11.4 years prospectively underwent testing for coronary endothelial function and measurement of coronary artery calcification (CAC).
Log CAC scores were not significantly different between patients with normal (n=31) and abnormal (n=15) response of epicardial coronary artery diameter to acetylcholine (%CAD(Ach)) (median (25, 75 percentile) 1.1 (0.0, 3.7) vs. 0.3 (0.0, 2.4), P=.32) and with normal (n=28) and abnormal (n=18) response of coronary blood flow to acetylcholine (%CBF(Ach)) (0.5 (0.0, 3.6) vs. 0.5 (0.0, 3.2), P=.76). Log CAC scores did not correlate with %CAD(Ach) (r=0.08, P=.59), %CBF(Ach) (r=0.14, P=.35).
In patients without significant coronary artery disease, coronary endothelial dysfunction showed no apparent association with coronary calcification. Our findings suggest that these 2 markers may represent separate, independent processes in the progression of coronary atherosclerosis.
冠状动脉内皮功能与冠状动脉钙化之间的关系尚未明确。
46 例患者(男 17 例[37%];年龄 47.4±11.4 岁)前瞻性地接受了冠状动脉内皮功能检测和冠状动脉钙化(CAC)测量。
乙酰胆碱引起的心外膜冠状动脉直径反应正常(n=31)和异常(n=15)(%CAD(Ach))的患者之间以及乙酰胆碱引起的冠状动脉血流反应正常(n=28)和异常(n=18)(%CBF(Ach))的患者之间的对数 CAC 评分无显著差异(中位数(25%,75%)为 1.1(0.0,3.7)比 0.3(0.0,2.4),P=.32)。对数 CAC 评分与 %CAD(Ach)(r=0.08,P=.59)和 %CBF(Ach)(r=0.14,P=.35)均无相关性。
在无明显冠状动脉疾病的患者中,冠状动脉内皮功能障碍与冠状动脉钙化无明显关联。我们的发现表明,这两种标志物可能代表冠状动脉粥样硬化进展中的两个独立的、独立的过程。