早期动脉粥样硬化中冠状动脉内皮功能与冠状动脉钙化的关系。
Relationship between coronary endothelial function and coronary calcification in early atherosclerosis.
机构信息
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Atherosclerosis. 2010 Mar;209(1):197-200. doi: 10.1016/j.atherosclerosis.2009.08.027. Epub 2009 Aug 21.
Abstract
BACKGROUND
The relationship between coronary endothelial function and coronary calcification is not well established.
METHODS
Forty-six patients 17 men [37%]; age, 47.4+/-11.4 years prospectively underwent testing for coronary endothelial function and measurement of coronary artery calcification (CAC).
RESULTS
Log CAC scores were not significantly different between patients with normal (n=31) and abnormal (n=15) response of epicardial coronary artery diameter to acetylcholine (%CAD(Ach)) (median (25, 75 percentile) 1.1 (0.0, 3.7) vs. 0.3 (0.0, 2.4), P=.32) and with normal (n=28) and abnormal (n=18) response of coronary blood flow to acetylcholine (%CBF(Ach)) (0.5 (0.0, 3.6) vs. 0.5 (0.0, 3.2), P=.76). Log CAC scores did not correlate with %CAD(Ach) (r=0.08, P=.59), %CBF(Ach) (r=0.14, P=.35).
CONCLUSIONS
In patients without significant coronary artery disease, coronary endothelial dysfunction showed no apparent association with coronary calcification. Our findings suggest that these 2 markers may represent separate, independent processes in the progression of coronary atherosclerosis.
摘要
背景
冠状动脉内皮功能与冠状动脉钙化之间的关系尚未明确。
方法
46 例患者（男 17 例[37%]；年龄 47.4±11.4 岁）前瞻性地接受了冠状动脉内皮功能检测和冠状动脉钙化（CAC）测量。
结果
乙酰胆碱引起的心外膜冠状动脉直径反应正常（n=31）和异常（n=15）（%CAD(Ach)）的患者之间以及乙酰胆碱引起的冠状动脉血流反应正常（n=28）和异常（n=18）（%CBF(Ach)）的患者之间的对数 CAC 评分无显著差异（中位数（25%，75%）为 1.1（0.0，3.7）比 0.3（0.0，2.4），P=.32）。对数 CAC 评分与 %CAD(Ach)（r=0.08，P=.59）和 %CBF(Ach)（r=0.14，P=.35）均无相关性。
结论
在无明显冠状动脉疾病的患者中，冠状动脉内皮功能障碍与冠状动脉钙化无明显关联。我们的发现表明，这两种标志物可能代表冠状动脉粥样硬化进展中的两个独立的、独立的过程。
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