载脂蛋白B祖先单倍型的鉴定表明智人起源于非洲，并追踪了他们随后向欧洲和太平洋的迁徙。
Identification of the ancestral haplotype for apolipoprotein B suggests an African origin of Homo sapiens sapiens and traces their subsequent migration to Europe and the Pacific.
作者信息
Rapacz J, Chen L, Butler-Brunner E, Wu M J, Hasler-Rapacz J O, Butler R, Schumaker V N
机构信息
Department of Genetics, University of Wisconsin, Madison.
出版信息
Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1403-6. doi: 10.1073/pnas.88.4.1403.
Abstract
The probable ancestral haplotype for human apolipoprotein B (apoB) has been identified through immunological analysis of chimpanzee and gorilla serum and sequence analysis of their DNA. Moreover, the frequency of this ancestral apoB haplotype among different human populations provides strong support for the African origin of Homo sapiens sapiens and their subsequent migration from Africa to Europe and to the Pacific. The approach used here for the identification of the ancestral human apoB haplotype is likely to be applicable to many other genes.
摘要
通过对黑猩猩和大猩猩血清的免疫学分析以及对它们DNA的序列分析，已确定了人类载脂蛋白B（apoB）可能的祖先单倍型。此外，这种祖先apoB单倍型在不同人类群体中的频率，为现代人类起源于非洲以及随后从非洲迁徙到欧洲和太平洋地区提供了有力支持。此处用于鉴定人类apoB祖先单倍型的方法可能适用于许多其他基因。
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