通过光刻工艺与微成型技术相结合制造的中空聚合物微针阵列。
Hollow polymer microneedle array fabricated by photolithography process combined with micromolding technique.
作者信息
Wang Po-Chun, Wester Brock A, Rajaraman Swaminathan, Paik Seung-Joon, Kim Seong-Hyok, Allen Mark G
机构信息
School of Electrical and Computer Engineering of Georgia Institute of Technology, Atlanta, GA 30332, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:7026-9. doi: 10.1109/IEMBS.2009.5333317.
Abstract
Transdermal drug delivery through microneedles is a minimally invasive procedure causing little or no pain, and is a potentially attractive alternative to intramuscular and subdermal drug delivery methods. This paper demonstrates the fabrication of a hollow microneedle array using a polymer-based process combining UV photolithography and replica molding techniques. The key characteristic of the proposed fabrication process is to define a hollow lumen for microfluidic access via photopatterning, allowing a batch process as well as high throughput. A hollow SU-8 microneedle array, consisting of 825mum tall and 400 mum wide microneedles with 15-25 mum tip diameters and 120 mum diameter hollow lumens was designed, fabricated and characterized.
摘要
通过微针进行透皮给药是一种微创程序，几乎不会引起疼痛，是肌肉注射和皮下给药方法潜在的有吸引力的替代方案。本文展示了一种基于聚合物的工艺制造空心微针阵列，该工艺结合了紫外光刻和复制成型技术。所提出的制造工艺的关键特性是通过光刻图案化定义用于微流体通道的空心内腔，从而实现批量工艺以及高通量。设计、制造并表征了一种空心SU-8微针阵列，其微针高825μm、宽400μm，尖端直径为15 - 25μm，空心内腔直径为120μm。
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本文引用的文献
1
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IEEE Eng Med Biol Mag. 2009 Jan-Feb;28(1):31-9. doi: 10.1109/MEMB.2008.931014.
2
Three dimensional MEMS microfluidic perfusion system for thick brain slice cultures.用于厚脑片培养的三维微机电系统微流体灌注系统。
Biomed Microdevices. 2007 Feb;9(1):7-13. doi: 10.1007/s10544-006-9004-8.
3
Mechanism of fluid infusion during microneedle insertion and retraction.微针插入和拔出过程中的液体输注机制。
J Control Release. 2006 May 30;112(3):357-61. doi: 10.1016/j.jconrel.2006.02.017. Epub 2006 Apr 19.
4
Hollow metal microneedles for insulin delivery to diabetic rats.用于向糖尿病大鼠递送胰岛素的中空金属微针。
IEEE Trans Biomed Eng. 2005 May;52(5):909-15. doi: 10.1109/TBME.2005.845240.
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J Control Release. 2005 May 5;104(1):51-66. doi: 10.1016/j.jconrel.2005.02.002. Epub 2005 Apr 1.
6
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7
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Adv Drug Deliv Rev. 2004 Mar 27;56(5):581-7. doi: 10.1016/j.addr.2003.10.023.
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