Tucak Amina, Sirbubalo Merima, Hindija Lamija, Rahić Ognjenka, Hadžiabdić Jasmina, Muhamedagić Kenan, Čekić Ahmet, Vranić Edina
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina.
Department of Machinery Production Engineering, Faculty of Mechanical Engineering, University of Sarajevo, Vilsonovo šetalište 9, 71000 Sarajevo, Bosnia and Herzegovina.
Micromachines (Basel). 2020 Oct 27;11(11):961. doi: 10.3390/mi11110961.
Although transdermal drug delivery systems (DDS) offer numerous benefits for patients, including the avoidance of both gastric irritation and first-pass metabolism effect, as well as improved patient compliance, only a limited number of active pharmaceutical ingredients (APIs) can be delivered accordingly. Microneedles (MNs) represent one of the most promising concepts for effective transdermal drug delivery that penetrate the protective skin barrier in a minimally invasive and painless manner. The first MNs were produced in the 90s, and since then, this field has been continually evolving. Therefore, different manufacturing methods, not only for MNs but also MN molds, are introduced, which allows for the cost-effective production of MNs for drug and vaccine delivery and even diagnostic/monitoring purposes. The focus of this review is to give a brief overview of MN characteristics, material composition, as well as the production and commercial development of MN-based systems.
尽管透皮给药系统（DDS）为患者带来了诸多益处，包括避免胃部刺激和首过代谢效应，以及提高患者的顺应性，但相应地只有有限数量的活性药物成分（API）能够通过该系统给药。微针（MNs）是有效透皮给药最具前景的概念之一，它以微创且无痛的方式穿透皮肤保护屏障。第一代微针于20世纪90年代问世，自那时起，该领域不断发展。因此，人们引入了不同的制造方法，不仅用于微针，还用于微针模具，这使得能够以具有成本效益的方式生产用于药物和疫苗递送甚至诊断/监测目的的微针。本综述的重点是简要概述微针的特性、材料组成，以及基于微针的系统的生产和商业发展情况。
