Wang Jitong, Zeng Jia, Liu Zhidan, Zhou Qin, Wang Xin, Zhao Fan, Zhang Yu, Wang Jiamiao, Liu Minchen, Du Ruofei
Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai 200032, China.
Pharmaceutics. 2022 Aug 19;14(8):1736. doi: 10.3390/pharmaceutics14081736.
Arthritis is a general term for various types of inflammatory joint diseases. The most common clinical conditions are mainly represented by rheumatoid arthritis and osteoarthritis, which affect more than 4% of people worldwide and seriously limit their mobility. Arthritis medication generally requires long-term application, while conventional administrations by oral delivery or injections may cause gastrointestinal side effects and are inconvenient for patients during long-term application. Emerging microneedle (MN) technology in recent years has created new avenues of transdermal delivery for arthritis drugs due to its advantages of painless skin perforation and efficient local delivery. This review summarizes various types of arthritis and current therapeutic agents. The current development of MNs in the delivery of arthritis drugs is highlighted, demonstrating their capabilities in achieving different drug release profiles through different self-enhancement methods or the incorporation of nanocarriers. Furthermore, the challenges of translating MNs from laboratory studies to the clinical practice and the marketplace are discussed. This promising technology provides a new approach to the current drug delivery paradigm in treating arthritis in transdermal delivery.
关节炎是各类炎症性关节疾病的统称。最常见的临床病症主要以类风湿性关节炎和骨关节炎为代表，全球超过4%的人受其影响，严重限制了他们的行动能力。关节炎药物通常需要长期使用，而传统的口服或注射给药方式可能会引起胃肠道副作用，且患者长期使用不便。近年来新兴的微针（MN）技术，因其无痛穿皮和高效局部给药的优势，为关节炎药物的透皮给药开辟了新途径。本文综述了各类关节炎及当前的治疗药物。重点介绍了微针在关节炎药物递送方面的当前进展，展示了其通过不同的自我增强方法或结合纳米载体实现不同药物释放曲线的能力。此外，还讨论了将微针从实验室研究转化为临床实践和市场应用所面临的挑战。这项有前景的技术为当前透皮给药治疗关节炎的药物递送模式提供了一种新方法。
