Rajadhyaksha Milind
Dermatology Service, Memorial Sloan-Kettering Cancer Center, 160 East 53 Street, New York, NY 10022, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:3231-3. doi: 10.1109/IEMBS.2009.5333600.
Recent advances in translational research in and technology for confocal microscopy of skin cancers, toward clinical applications, are described. Advances in translational research are in diagnosis of melanoma in vivo, pre-operative mapping of lentigo maligna melanoma margins to guide surgery and intra-operative imaging of residual basal cell carcinomas to guide shave-biopsy. Advances in technology include mosaicing microscopy for detection of basal cell carcinomas in large areas of excised tissue, toward rapid pathology-at-the-bedside, and development of small, simple and low-cost line-scanning confocal microscopes for worldwide use in diverse primary healthcare settings. Current limitations and future opportunities and challenges for both clinicians and technologists are discussed.
本文描述了皮肤癌共聚焦显微镜检查在转化研究及技术方面朝着临床应用方向取得的最新进展。转化研究的进展包括黑色素瘤的体内诊断、恶性雀斑样痣黑色素瘤边缘的术前定位以指导手术，以及残余基底细胞癌的术中成像以指导刮除活检。技术进展包括用于在切除组织的大面积区域检测基底细胞癌的拼接显微镜，以实现快速床边病理检查，以及开发小型、简单且低成本的线扫描共聚焦显微镜，供全球不同基层医疗环境使用。文中还讨论了临床医生和技术专家目前面临的局限性以及未来的机遇与挑战。
