Huiskamp Geertjan, Agirre-Arrizubieta Zaloa
Department of Neurology and Clinical Neurophysiology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, F02.230 Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. ghuiskam@ umcutrecht.nl
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1930-3. doi: 10.1109/IEMBS.2009.5333922.
This study investigates the relationship between the sources of MEG interictal spikes and the distribution of spikes in invasive ECoG in a group of 38 epilepsy patients. An amplitude/surface area measure is defined to quantify ECoG spikes. It is found that all MEG spikes are associated with an ECoG spike that is, according to this measure, among the largest in each patient. For different brain regions considered the inter-hemispheric, tempero-lateral and central regions stand out. However, MEG may only see part of the often complex ECoG spike. In an accompanying simulation study it is shown that MEG as predicted from measured complex ECoG spikes resemble measured MEG and show similar shortcomings with respect to localization.
本研究调查了38例癫痫患者中，MEG发作间期棘波的来源与侵入性ECoG中棘波分布之间的关系。定义了一种幅度/表面积测量方法来量化ECoG棘波。研究发现，所有MEG棘波都与一个ECoG棘波相关，根据该测量方法，该ECoG棘波在每个患者中都是最大的之一。对于所考虑的不同脑区，半球间、颞外侧和中央区域较为突出。然而，MEG可能只能看到通常复杂的ECoG棘波的一部分。在一项配套的模拟研究中表明，根据测量的复杂ECoG棘波预测的MEG与测量的MEG相似，并且在定位方面表现出类似的缺点。
