Aoi Mikio, Gremaud Pierre, Tran Hien T, Novak Vera, Olufsen Mette S
Biomathematics Program, North Carolina State University, Raleigh, NC 26795, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:5470-3. doi: 10.1109/IEMBS.2009.5334057.
Cerebral autoregulation is a homeostatic mechanism which maintains blood flow despite changes in blood pressure in order to meet local metabolic demands. Several mechanisms play a role in cerebral autoregulation in order to adjust vascular tone and caliber of the cerebral vessels, but the exact etiology of the dynamics of these mechanism is not well understood. In this study, we discuss two patient specific models predicting cerebral blood flow velocity during postural change from sitting to standing. One model characterises cerebral autoregulation, the other describes the beat-to-beat distribution of blood flow to the major regions of the brain. Both models have been validated against experimental data from a healthy young subject.
脑自动调节是一种稳态机制，它能在血压变化时维持血流，以满足局部代谢需求。为了调节脑血管的血管张力和管径，几种机制在脑自动调节中发挥作用，但这些机制动态变化的确切病因尚不清楚。在本研究中，我们讨论了两个针对特定患者的模型，用于预测从坐姿到站姿姿势改变过程中的脑血流速度。一个模型表征脑自动调节，另一个描述大脑主要区域的逐搏血流分布。这两个模型均已根据一名健康年轻受试者的实验数据进行了验证。
