关于航天相关神经-眼综合征中视神经脑脊液流出的假说。
Hypothesis on the outflow of optic nerve cerebrospinal fluid in spaceflight associated neuro ocular syndrome.
作者信息
Hu Yuwei, Lin Yuanxi, Cheng Lu, Xu Yang, Zhang Jian, Zheng Zheng, Wang Huan, Yan Min, Chen Hui
机构信息
Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan, China.
Key laboratory of transfusion adverse reactions, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China.
出版信息
NPJ Microgravity. 2024 Dec 19;10(1):112. doi: 10.1038/s41526-024-00449-6.
Spaceflight-associated neuro-ocular syndrome (SANS) has been well documented in astronauts. However, its pathogenesis is not fully understood. New findings indicate the impaired outflow of the optic nerve cerebrospinal fluid may participate or contribute to some changes in SANS. In this perspective, we generated a hypothesis that the outflow of cerebrospinal fluid through the optic nerve sheath may be impaired under micro-gravity and then may potentially lead to SANS-related alterations.
太空飞行相关神经眼科综合征（SANS）在宇航员中已有充分记录。然而，其发病机制尚未完全明确。新的研究结果表明，视神经脑脊液流出受损可能参与或导致了SANS的某些变化。从这个角度来看，我们提出了一个假设，即在微重力条件下，脑脊液通过视神经鞘的流出可能会受损，进而可能导致与SANS相关的改变。
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