Cregan P, Donegan E, Gotelli G
Department of Laboratory Medicine, University of California, San Francisco.
Transfusion. 1991 Feb;31(2):172-5. doi: 10.1046/j.1537-2995.1991.31291142950.x.
A case of hemolytic transfusion reaction, accompanied by hypotension and followed by transient renal failure, occurred after the transfusion of 1 unit of previously frozen autologous red cells. Subsequent investigation revealed the probable cause of the hemolysis to be inadequate deglycerolization of the unit. The cause of the associated symptoms is unknown. Possibilities include nephrotoxic effects of hemoglobin or stroma, toxic effects of glycerol, or release of vasoactive or thrombogenic substances from lysed red cells. This case of a hemolytic reaction adds to the known risks of autologous transfusion.
1单位先前冷冻的自体红细胞输注后发生了溶血性输血反应，伴有低血压，随后出现短暂性肾衰竭。后续调查显示，溶血的可能原因是该单位红细胞甘油去除不充分。相关症状的原因尚不清楚。可能的原因包括血红蛋白或基质的肾毒性作用、甘油的毒性作用，或溶血红细胞释放血管活性物质或促血栓形成物质。这例溶血反应病例增加了自体输血已知的风险。
