光流控环形谐振器概述：用于无标记生物和化学传感的多功能平台。

Overview of the optofluidic ring resonator: a versatile platform for label-free biological and chemical sensing.

作者信息

Suter Jonathan D, Fan Xudong

机构信息

Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1042-4. doi: 10.1109/IEMBS.2009.5335153.

DOI:10.1109/IEMBS.2009.5335153

PMID:19965134

Abstract

Highly sensitive detection of biological and chemical analytes has significant importance within medical science, environmental monitoring, food quality, national security and defense. The opto-fluidic ring resonator (OFRR) is a relatively new solution for label-free optical sensing that is compatible with a versatile range of analytes. A capillary-based platform, the OFRR supports whispering gallery modes within its circular cross-section and conducts evanescent sensing within its hollow core. Herein, we provide an overview of the basic operation principles of the OFRR and some examples of its most important applications, including the detection of proteins, virus, DNA molecules, whole cells, vapors and pesticides.

摘要

对生物和化学分析物进行高灵敏度检测在医学、环境监测、食品质量、国家安全和国防等领域具有重要意义。光流体环形谐振器（OFRR）是一种相对较新的无标记光学传感解决方案，可兼容多种分析物。作为基于毛细管的平台，OFRR在其圆形横截面内支持回音壁模式，并在其空心核心内进行倏逝传感。在此，我们概述了OFRR的基本工作原理及其一些最重要应用的示例，包括蛋白质、病毒、DNA分子、全细胞、蒸汽和农药的检测。