Habibi Mohammad, Klemer David P, Raicu Valerica
Department of Electrical Engineering and Computer Science, University of Wisconsin-Milwaukee, Milwaukee, WI 53201-0784, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:2284-7. doi: 10.1109/IEMBS.2009.5335076.
Various tissue properties have been used in the past and present as metrics which can serve to discriminate healthy from diseased tissue. Electromagnetic absorption (of x-rays and optical signals), scattering of near-infrared light, and electrical impedance are a few such parameters. In order to serve as discriminants for diseased (e.g., neoplastic) tissue, the characteristics of these tissues must first be precisely determined. In this paper, we consider the electrical impedance properties of tissues and cell aggregates, and present the design of a reconfigurable electrode array which is capable of providing a well-defined electromagnetic interface to the tissue under study, for characterization in the 0.01-30 MHz range. The configuration of array elements may be easily changed under digital control, allowing for various electromagnetic field configurations to be applied to the tissue under study. The array is designed to interface to four-point as well as two-point impedance instrumentation, and may be used for two-dimensional bioimaging systems based on electrical impedances. The design may be scaled to higher frequencies and smaller dimensions, allowing for studies of electrical properties at the cellular level.
过去和现在，人们使用了各种组织特性作为指标，以区分健康组织和患病组织。（X射线和光信号的）电磁吸收、近红外光散射以及电阻抗就是这样一些参数。为了作为患病（如肿瘤）组织的判别指标，必须首先精确确定这些组织的特性。在本文中，我们考虑组织和细胞聚集体的电阻抗特性，并介绍一种可重构电极阵列的设计，该阵列能够为所研究的组织提供明确的电磁界面，以便在0.01 - 30 MHz范围内进行表征。阵列元件的配置可以在数字控制下轻松改变，从而能够将各种电磁场配置应用于所研究的组织。该阵列设计用于连接四点和两点阻抗测量仪器，可用于基于电阻抗的二维生物成像系统。该设计可以扩展到更高频率和更小尺寸，以便在细胞水平上研究电学特性。
