Khurram Abeer, Seymour John P
Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:3032-5. doi: 10.1109/EMBC.2013.6610179.
The combination of optical stimulation and electrical recording is commonly employed in neuroscience research. Researchers using optogenetics are familiar with the photo-induced "artifacts" that arise from illumination of an electrode array. We sought to characterize this photoelectrochemical (PEC) effect to understand the underlying mechanism seen on NeuroNexus optoelectrodes. In doing so, we discovered that the phenomenon is inversely proportional to electrode site area in the same manner as electrical impedance measurements. We have applied the PEC effect as a method of electrode evaluation and show that a PEC measurement system can be both faster and more effective than impedance at sensing defects in high-throughput biomedical device testing.
光刺激与电记录相结合的方法在神经科学研究中被广泛应用。使用光遗传学的研究人员对电极阵列受光照产生的光诱导“伪迹”并不陌生。我们试图对这种光电化学（PEC）效应进行表征，以了解在NeuroNexus光电电极上观察到的潜在机制。在此过程中，我们发现该现象与电极位点面积成反比，这与电阻抗测量的方式相同。我们已将PEC效应应用于电极评估方法，并表明在高通量生物医学设备测试中，PEC测量系统在检测缺陷方面比阻抗测量更快、更有效。
