Fortún J, Martín-Dávila P, Méndez R, Martínez A, Norman F, Rubi J, Pallares E, Gómez-Mampaso E, Moreno S
Infectious Diseases Department Ramón y Cajal Hospital, Madrid, Spain.
Open Respir Med J. 2009 Nov 20;3:123-7. doi: 10.2174/1874306400903010123.
Ca-125 is secreted by different celomic epitheliums. Serum levels may be increased in malignant diseases, like ovarian cancer but also in other medical conditions, such as pulmonary and extrapulmonary tuberculosis.
From Jan-04 to Dec-06 a retrospective study analyzing Ca-125 levels in serum samples from patients with a diagnosis of pulmonary TB, was performed. These results were compared with those samples obtained from patients with non-TB pulmonary infections.
Eighty-nine patients were included in the study, thirty-five with pulmonary TB and 54 with other respiratory infections. In patients with TB, the mean Ca-125 value was 104.9 IU/ml (SD: +/- 136.1). In the control group, mean value was 27.1 IU/ml (SD: +/-19.7). The optimal cut-off for pulmonary tuberculosis was 32.5 IU/ml (sensitivity: 68.6%, specificity: 77.8%). Pulmonary TB was the only factor associated with a Ca-125 level >32.5. In 10 patients with TB, Ca-125 levels were available >/= 2 months after starting TB therapy and a decrease during treatment was shown.
Ca-125 values increase in patients with pulmonary TB and decline to normal values during treatment. Determination of Ca 125 may be usedin patients with a negative sputum AFB stain.
Ca-125由不同的体腔上皮分泌。血清水平在恶性疾病（如卵巢癌）中可能升高，但在其他病症（如肺结核和肺外结核）中也会升高。
对2004年1月至2006年12月期间诊断为肺结核患者的血清样本中Ca-125水平进行回顾性研究分析。将这些结果与非结核性肺部感染患者的样本结果进行比较。
该研究纳入了89例患者，其中35例患有肺结核，54例患有其他呼吸道感染。肺结核患者的Ca-125平均值为104.9 IU/ml（标准差：±136.1）。对照组的平均值为27.1 IU/ml（标准差：±19.7）。肺结核的最佳临界值为32.5 IU/ml（敏感性：68.6%，特异性：77.8%）。肺结核是与Ca-125水平>32.5相关的唯一因素。在10例肺结核患者中，开始抗结核治疗2个月及以上时可获得Ca-125水平，且治疗期间显示其下降。
肺结核患者的Ca-125值升高，治疗期间降至正常水平。Ca-125测定可用于痰涂片抗酸杆菌染色阴性的患者。
