Department of Biostatistics, School of Public Health, University of California Los Angeles, CHS 51-254, Box 951772, Los Angeles, CA, 90095-1772, USA.
J Cancer Surviv. 2010 Mar;4(1):45-58. doi: 10.1007/s11764-009-0106-1. Epub 2009 Dec 6.
Self-report instruments such as the Impact of Cancer (IOC) are designed to measure quality of life (QOL) impacts that cancer survivors attribute to their cancer experience. Generalizability of QOL findings across distinct diagnostic categories of survivors is untested. We compare measurement of the impact of cancer using the IOC instrument in breast cancer (BC) survivors (n = 1,188) and non-Hodgkin lymphoma (NHL) survivors (n = 652).
A registry-based sample of NHL survivors completed the IOC questionnaire and the FACT-G, FACT-LYM, Medical Outcomes Study (MOS) SF-36, Post-Traumatic Stress Disorder Checklist-Civilian Version, Post-Traumatic Growth Inventory and MOS Social Support scales. IOC responses of the NHL survivors were subjected to de novo scaling to identify impact domains for comparison to IOC version 2 (IOCv2) domains, which were previously developed based on BC survivor responses. Concurrent validity was assessed by correlating the IOCv2 scales with the other measures. IOCv2 scores were compared between the BC and NHL survivor samples.
The BC and NHL survivors exhibited similar impact domains and had factor structures that were largely congruent. The concurrent validity analysis revealed patterns of association that supported the interpretation and validity of the IOCv2 scales. Differences in IOCv2 scores between the BC and NHL groups suggested differential impacts in distinct survivor groups that could be detected using the IOCv2.
The results suggest that the IOCv2 measures common and important survivor concerns and support its generalizability to the broader long-term cancer survivor population.
Instruments such as the IOCv2 can provide valid assessment of QOL impacts in long-term cancer survivors, facilitating the characterization of these impacts and development of appropriate interventions.
自我报告工具，如癌症影响量表（IOC），旨在衡量癌症幸存者归因于其癌症经历的生活质量（QOL）影响。尚未测试 QOL 发现是否在不同的幸存者诊断类别中具有普遍性。我们比较了使用 IOC 工具在乳腺癌（BC）幸存者（n = 1,188）和非霍奇金淋巴瘤（NHL）幸存者（n = 652）中测量癌症影响的情况。
一项基于登记的 NHL 幸存者样本完成了 IOC 问卷和 FACT-G、FACT-LYM、医疗结局研究（MOS）SF-36、平民版创伤后应激障碍检查表、创伤后成长量表和 MOS 社会支持量表。对 NHL 幸存者的 IOC 反应进行了重新定标，以确定影响领域，以便与之前基于 BC 幸存者反应开发的 IOC 第 2 版（IOCv2）领域进行比较。通过将 IOCv2 量表与其他测量值进行相关性评估来评估同时效度。比较了 BC 和 NHL 幸存者样本之间的 IOCv2 得分。
BC 和 NHL 幸存者表现出相似的影响领域，且具有很大程度上一致的因素结构。同时效度分析显示了支持 IOCv2 量表解释和有效性的关联模式。BC 和 NHL 组之间 IOCv2 得分的差异表明，在不同的幸存者群体中存在不同的影响，而 IOCv2 可以检测到这些影响。
结果表明，IOCv2 测量方法能够衡量普遍存在的重要幸存者关注点，支持其在更广泛的长期癌症幸存者群体中的普遍性。
IOCv2 等工具可以为长期癌症幸存者的生活质量影响提供有效评估，有助于描述这些影响并制定适当的干预措施。
