Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
Psychooncology. 2010 Dec;19(12):1259-67. doi: 10.1002/pon.1684.
Recent work suggests that perceptions of the impact of cancer on survivors' lives are associated with physical and mental health and quality of life (QOL) outcomes. This study examines the association between the Impact of Cancer Version 2 Scales (IOCv2) and these outcomes in a large sample of survivors of adult non-Hodgkin lymphoma (NHL).
Participants completed a mailed survey to assess physical and mental health (SF-36), cancer-specific QOL (FACT-G) and perceived impact of cancer (IOCv2). Hierarchical multiple regression models, in which demographic, clinical, psychosocial and IOCv2 measures were added sequentially, were employed to evaluate their contribution to explain variance in SF-36 and FACT-G scores.
A total of 652 post-treatment NHL survivors participated. Survivors with comorbidities and negative appraisals of life threat and treatment intensity reported worse physical and mental health and QOL (all p<0.05). After controlling for demographic and clinical characteristics, younger respondents reported better physical but worse mental health and QOL (all p<0.01). Lower IOCv2 Negative Impact (all p<0.001) and higher Positive Impact (all p<0.05) scores were associated with better physical and mental health and QOL after controlling for demographic, clinical and psychosocial characteristics.
Findings suggest that perceptions of cancer's impact on survivors' lives may influence or be influenced by health status and functioning and QOL. Longitudinal research is needed to establish causality, which could lead to the development of interventions targeting survivors' impact of cancer concerns, and ultimately to the enhancement of overall health and QOL.
最近的研究表明，对癌症对幸存者生活影响的认知与身心健康和生活质量（QOL）结果相关。本研究在大量非霍奇金淋巴瘤（NHL）成年幸存者样本中，考察了癌症影响量表 2 版（IOCv2）与这些结果之间的关联。
参与者完成了一项邮寄调查，以评估身心健康（SF-36）、癌症特异性 QOL（FACT-G）和对癌症的感知影响（IOCv2）。采用分层多重回归模型，逐步加入人口统计学、临床、心理社会和 IOCv2 指标，评估它们对 SF-36 和 FACT-G 评分的解释方差的贡献。
共有 652 名治疗后 NHL 幸存者参与了研究。患有合并症、对生命威胁和治疗强度的负面评估的幸存者报告了更差的身心健康和 QOL（均 p<0.05）。在控制人口统计学和临床特征后，年轻的受访者报告了更好的身体健康，但更差的心理健康和 QOL（均 p<0.01）。在控制人口统计学、临床和心理社会特征后，IOCv2 负向影响（均 p<0.001）和正向影响（均 p<0.05）得分较低与更好的身心健康和 QOL相关。
研究结果表明，对癌症对幸存者生活影响的认知可能会影响健康状况和功能以及 QOL，也可能受到健康状况和功能以及 QOL 的影响。需要进行纵向研究以确定因果关系，这可能会导致针对幸存者对癌症担忧的影响的干预措施的发展，并最终提高整体健康和 QOL。
