Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Nano Lett. 2010 Jan;10(1):52-8. doi: 10.1021/nl902659g.
Effective and specific targeting of nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an alpha(v)beta(3) integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting.
有效的和特定的纳米粒子靶向在靶向治疗和诊断领域至关重要。在目前的研究中，我们研究了纳米粒子的靶向功效，这些纳米粒子功能化的两种血管生成特异性靶向配体，一个 alpha(v)beta(3)整合素特异性和一个半乳糖凝集素-1 特异性肽。我们在体外使用光学技术和 MRI 显示，双重靶向方法产生协同靶向效应，导致纳米粒子的摄取显著增加，与单配体靶向相比。
