• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于DNA适配体的逻辑门

Logic Gates Based on DNA Aptamers.

作者信息

Andrianova Mariia, Kuznetsov Alexander

机构信息

Scientific-Manufacturing Complex Technological Centre, 1-7 Shokin Square, Zelenograd, 124498 Moscow, Russia.

出版信息

Pharmaceuticals (Basel). 2020 Nov 23;13(11):417. doi: 10.3390/ph13110417.

DOI:10.3390/ph13110417
PMID:33238657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7700249/
Abstract

DNA bio-computing is an emerging trend in modern science that is based on interactions among biomolecules. Special types of DNAs are aptamers that are capable of selectively forming complexes with target compounds. This review is devoted to a discussion of logic gates based on aptamers for the purposes of medicine and analytical chemistry. The review considers different approaches to the creation of logic gates and identifies the general algorithms of their creation, as well as describes the methods of obtaining an output signal which can be divided into optical and electrochemical. Aptameric logic gates based on DNA origami and DNA nanorobots are also shown. The information presented in this article can be useful when creating new logic gates using existing aptamers and aptamers that will be selected in the future.

摘要

DNA生物计算是现代科学中一种基于生物分子间相互作用的新兴趋势。特殊类型的DNA是适配体，能够与靶标化合物选择性地形成复合物。本综述致力于讨论基于适配体的逻辑门在医学和分析化学中的应用。该综述考虑了创建逻辑门的不同方法，确定了其创建的通用算法，并描述了获得输出信号的方法，输出信号可分为光学信号和电化学信号。还展示了基于DNA折纸和DNA纳米机器人的适配体逻辑门。当利用现有适配体以及未来将筛选出的适配体创建新的逻辑门时，本文所呈现的信息可能会有所帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/da4e0b2dafeb/pharmaceuticals-13-00417-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/7a3c817e153b/pharmaceuticals-13-00417-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/6d0991db1656/pharmaceuticals-13-00417-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/f265cc2a3c94/pharmaceuticals-13-00417-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/844516c1335b/pharmaceuticals-13-00417-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/87b7d71ea669/pharmaceuticals-13-00417-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/6d0a3820708e/pharmaceuticals-13-00417-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/939a95909ba0/pharmaceuticals-13-00417-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/fc23d13f6b6c/pharmaceuticals-13-00417-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/04d2439b0682/pharmaceuticals-13-00417-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/0a3f5150f42f/pharmaceuticals-13-00417-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/c15197df36cb/pharmaceuticals-13-00417-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/e6aa82fab75e/pharmaceuticals-13-00417-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/e6568238fbcb/pharmaceuticals-13-00417-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/46a4b354db22/pharmaceuticals-13-00417-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/dc42d99f0e3f/pharmaceuticals-13-00417-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/98235e88d6f2/pharmaceuticals-13-00417-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/85e85516a3bb/pharmaceuticals-13-00417-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/660d47c236a7/pharmaceuticals-13-00417-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/d6fa47b2632d/pharmaceuticals-13-00417-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/94c0363fdd36/pharmaceuticals-13-00417-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/5311fc6375a7/pharmaceuticals-13-00417-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/da4e0b2dafeb/pharmaceuticals-13-00417-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/7a3c817e153b/pharmaceuticals-13-00417-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/6d0991db1656/pharmaceuticals-13-00417-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/f265cc2a3c94/pharmaceuticals-13-00417-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/844516c1335b/pharmaceuticals-13-00417-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/87b7d71ea669/pharmaceuticals-13-00417-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/6d0a3820708e/pharmaceuticals-13-00417-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/939a95909ba0/pharmaceuticals-13-00417-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/fc23d13f6b6c/pharmaceuticals-13-00417-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/04d2439b0682/pharmaceuticals-13-00417-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/0a3f5150f42f/pharmaceuticals-13-00417-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/c15197df36cb/pharmaceuticals-13-00417-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/e6aa82fab75e/pharmaceuticals-13-00417-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/e6568238fbcb/pharmaceuticals-13-00417-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/46a4b354db22/pharmaceuticals-13-00417-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/dc42d99f0e3f/pharmaceuticals-13-00417-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/98235e88d6f2/pharmaceuticals-13-00417-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/85e85516a3bb/pharmaceuticals-13-00417-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/660d47c236a7/pharmaceuticals-13-00417-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/d6fa47b2632d/pharmaceuticals-13-00417-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/94c0363fdd36/pharmaceuticals-13-00417-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/5311fc6375a7/pharmaceuticals-13-00417-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7703/7700249/da4e0b2dafeb/pharmaceuticals-13-00417-g022.jpg

相似文献

1
Logic Gates Based on DNA Aptamers.基于DNA适配体的逻辑门
Pharmaceuticals (Basel). 2020 Nov 23;13(11):417. doi: 10.3390/ph13110417.
2
Fluorogenic RNA Aptamers: A Nano-platform for Fabrication of Simple and Combinatorial Logic Gates.荧光RNA适配体：一种用于构建简单和组合逻辑门的纳米平台。
Nanomaterials (Basel). 2018 Nov 28;8(12):984. doi: 10.3390/nano8120984.
3
Construction of a fuzzy and Boolean logic gates based on DNA.基于 DNA 的模糊和布尔逻辑门的构建。
Small. 2015 Apr 17;11(15):1811-7. doi: 10.1002/smll.201402755. Epub 2015 Jan 7.
4
Multi-level logic gate operation based on amplified aptasensor performance.基于放大适配体传感器性能的多级逻辑门操作。
Angew Chem Int Ed Engl. 2015 Jun 22;54(26):7693-7. doi: 10.1002/anie.201502315. Epub 2015 May 8.
5
Surface-confined assemblies and polymers for molecular logic.用于分子逻辑的表面受限组装体和聚合物。
Acc Chem Res. 2011 Aug 16;44(8):563-73. doi: 10.1021/ar200002v. Epub 2011 Jun 16.
6
Complete all-optical processing polarization-based binary logic gates and optical processors.完成全光处理的基于偏振的二进制逻辑门和光学处理器。
Opt Express. 2006 Oct 16;14(21):9879-95. doi: 10.1364/oe.14.009879.
7
The Construction of DNA Logic Gates Restricted to Certain Live Cells Based on the Structure Programmability and Aptamer-Cell Affinity of G-Quadruplexes.基于 G-四链体结构可编程性和适体-细胞亲和力的特定活细胞内 DNA 逻辑门的构建。
Chemistry. 2021 Aug 11;27(45):11627-11632. doi: 10.1002/chem.202100913. Epub 2021 Jun 25.
8
Bioelectronic Interface Connecting Reversible Logic Gates Based on Enzyme and DNA Reactions.基于酶和DNA反应连接可逆逻辑门的生物电子界面。
Chemphyschem. 2016 Jul 18;17(14):2247-55. doi: 10.1002/cphc.201600129. Epub 2016 May 11.
9
Catalyst-based biomolecular logic gates.基于催化剂的生物分子逻辑门。
Catalysts. 2022 Jul;12(7). doi: 10.3390/catal12070712. Epub 2022 Jun 29.
10
Aptamer-Binding Directed DNA Origami Pattern for Logic Gates.适体结合导向 DNA 折纸图案用于逻辑门。
ACS Appl Mater Interfaces. 2016 Dec 14;8(49):34054-34060. doi: 10.1021/acsami.6b10266. Epub 2016 Dec 2.

引用本文的文献

1
Drug-Loaded Bioscaffolds for Osteochondral Regeneration.用于骨软骨再生的载药生物支架
Pharmaceutics. 2024 Aug 21;16(8):1095. doi: 10.3390/pharmaceutics16081095.
2
Aptamers' Potential to Fill Therapeutic and Diagnostic Gaps.适配体填补治疗和诊断空白的潜力。
Pharmaceuticals (Basel). 2024 Jan 12;17(1):105. doi: 10.3390/ph17010105.
3
Photocleavable -Nitrobenzyl-Protected DNA Architectures and Their Applications.光解硝基苄基保护的 DNA 结构及其应用。

本文引用的文献

1
"Plug and Play" logic gate construction based on chemically triggered fluorescence switching of gold nanoparticles conjugated with Cy3-tagged aptamer.基于与 Cy3 标记的适体偶联的金纳米粒子的化学触发荧光开关的“即插即用”逻辑门构建。
Mikrochim Acta. 2020 Jul 9;187(8):437. doi: 10.1007/s00604-020-04421-5.
2
Homogeneous DNA-only keypad locks enable one-pot assay of multi-inputs.同质 DNA 密码锁可实现多输入一键式检测。
Chem Commun (Camb). 2020 Jul 11;56(54):7427-7430. doi: 10.1039/d0cc02868a. Epub 2020 Jun 3.
3
Programmable DNA Nanoindicator-Based Platform for Large-Scale Square Root Logic Biocomputing.
Chem Rev. 2023 May 24;123(10):6839-6887. doi: 10.1021/acs.chemrev.3c00016. Epub 2023 Apr 20.
4
Controllable DNA nanodevices regulated by logic gates for multi-stimulus recognition.由逻辑门调控的用于多刺激识别的可控DNA纳米器件。
RSC Adv. 2023 Mar 20;13(13):9003-9009. doi: 10.1039/d3ra00295k. eCollection 2023 Mar 14.
5
Implementation of novel boolean logic gates for IMPLICATION and XOR functions using riboregulators.利用核糖开关实现蕴涵和异或函数的新型布尔逻辑门。
Bioengineered. 2022 Jan;13(1):1235-1248. doi: 10.1080/21655979.2021.2020493.
可编程 DNA 纳米示踪剂平台用于大规模平方根逻辑生物计算。
Small. 2019 Dec;15(49):e1903489. doi: 10.1002/smll.201903489. Epub 2019 Oct 29.
4
Logic-Gate-Actuated DNA-Controlled Receptor Assembly for the Programmable Modulation of Cellular Signal Transduction.逻辑门控 DNA 控制的受体组装用于细胞信号转导的可编程调节。
Angew Chem Int Ed Engl. 2019 Dec 9;58(50):18186-18190. doi: 10.1002/anie.201908971. Epub 2019 Oct 24.
5
Construction of a Multiple-Aptamer-Based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification.基于关联引发的适体组装构建活细胞膜上的 DNA 逻辑器件用于精确的癌细胞识别。
J Am Chem Soc. 2019 Aug 14;141(32):12738-12743. doi: 10.1021/jacs.9b05470. Epub 2019 Aug 1.
6
Principles and Applications of Nucleic Acid Strand Displacement Reactions.核酸链置换反应的原理及应用
Chem Rev. 2019 May 22;119(10):6326-6369. doi: 10.1021/acs.chemrev.8b00580. Epub 2019 Feb 4.
7
Electrochemical aptamer-based sensors for food and water analysis: A review.基于电化学适体的食品和水分析传感器：综述。
Anal Chim Acta. 2019 Mar 21;1051:1-23. doi: 10.1016/j.aca.2018.10.058. Epub 2018 Oct 26.
8
Dual-Analyte Chronopotentiometric Aptasensing Platform Based on a G-Quadruplex/Hemin DNAzyme and Logic Gate Operations.基于 G-四链体/辣根过氧化物酶 DNA zyme 的双分析物恒电流安培适体传感平台及逻辑门操作。
Anal Chem. 2019 Feb 19;91(4):3170-3176. doi: 10.1021/acs.analchem.8b05971. Epub 2019 Jan 30.
9
Fluorogenic RNA Aptamers: A Nano-platform for Fabrication of Simple and Combinatorial Logic Gates.荧光RNA适配体：一种用于构建简单和组合逻辑门的纳米平台。
Nanomaterials (Basel). 2018 Nov 28;8(12):984. doi: 10.3390/nano8120984.
10
DNA Aptamers for the Functionalisation of DNA Origami Nanostructures.用于DNA折纸纳米结构功能化的DNA适配体
Genes (Basel). 2018 Nov 23;9(12):571. doi: 10.3390/genes9120571.