纳米颗粒与肿瘤微环境的相互作用。

Stephenson School of Biomedical Engineering , University of Oklahoma , Norman , Oklahoma 73072 , United States.

Bioconjug Chem. 2019 Sep 18;30(9):2247-2263. doi: 10.1021/acs.bioconjchem.9b00448. Epub 2019 Sep 5.

Compared to normal tissues, the tumor microenvironment (TME) has a number of aberrant characteristics including hypoxia, acidosis, and vascular abnormalities. Many researchers have sought to exploit these anomalous features of the TME to develop anticancer therapies, and several nanoparticle-based cancer therapeutics have resulted. In this Review, we discuss the composition and pathophysiology of the TME, introduce nanoparticles (NPs) used in cancer therapy, and address the interaction between the TME and NPs. Finally, we outline both the potential problems that affect TME-based nanotherapy and potential strategies to overcome these challenges.

与正常组织相比，肿瘤微环境（TME）具有许多异常特征，包括缺氧、酸中毒和血管异常。许多研究人员试图利用 TME 的这些异常特征来开发抗癌疗法，由此产生了几种基于纳米粒子的癌症治疗方法。在这篇综述中，我们讨论了 TME 的组成和病理生理学，介绍了用于癌症治疗的纳米粒子（NPs），并讨论了 TME 与 NPs 之间的相互作用。最后，我们概述了影响基于 TME 的纳米治疗的潜在问题以及克服这些挑战的潜在策略。