Centro Grandi Apparecchiature, Second University of Naples, Naples, Italy.
Ophthalmology. 2010 Feb;117(2):223-5. doi: 10.1016/j.ophtha.2009.07.003. Epub 2009 Dec 6.
To compare the characteristics of the endothelial cells of patients with myotonic dystrophy and those of normal subjects to determine if thicker corneas in patients with myotonic dystrophy are the result of their having abnormal endothelial cells leading to corneal edema.
Prospective, comparative case series.
Fifty-two eyes of patients with myotonic dystrophy and 52 eyes of normal age- and gender-matched subjects.
Central corneal thickness (CCT) and endothelial cell counts and shape were measured with an SP 3000P specular microscope (Topcon, Tokyo, Japan) in patients with myotonic dystrophy and were compared with those of age- and gender-matched healthy subjects.
Central corneal thickness, endothelial cell counts, pleomorphism, and coefficient of variation (CoV).
In patients with myotonic dystrophy, the mean+/-standard deviation CCT measurement was 533+/-38 microm; the mean+/-standard deviation cell count was 2601+/-365 cell/mm(2); and the mean+/-standard deviation CoV was 23.3+/-4.4 (P<0.001). The mean+/-standard deviation pleomorphism was 64.4+/-8.4%. In healthy subjects, the mean+/-standard deviation CCT measurement was 514+/-27 microm (P = 0.002); the mean+/-standard deviation cell count was 2649+/-363 cell/mm(2) (P = 0.48); the mean+/-standard deviation CoV was 27.6+/-5.5 (P<0.001); and the mean+/-standard deviation pleomorphism was 61.1+/-8.6% (P = 0.04).
Thicker corneas found in patients with myotonic dystrophy are not related to endothelial number or appearance as assessed in this study.
比较肌强直性营养不良症患者与正常人群的内皮细胞特征，以确定肌强直性营养不良症患者的角膜较厚是否是由于其内皮细胞异常导致角膜水肿所致。
前瞻性、对照病例系列研究。
52 只肌强直性营养不良症患者的眼睛和 52 只年龄和性别匹配的正常对照者的眼睛。
使用 SP 3000P 共焦显微镜（Topcon，东京，日本）测量肌强直性营养不良症患者的中央角膜厚度（CCT）和内皮细胞计数及形态，并与年龄和性别匹配的健康对照者进行比较。
中央角膜厚度、内皮细胞计数、非整倍性和变异系数（CoV）。
肌强直性营养不良症患者的平均+/-标准差 CCT 测量值为 533+/-38 微米；平均+/-标准差细胞计数为 2601+/-365 个细胞/mm²；平均+/-标准差 CoV 为 23.3+/-4.4（P<0.001）。平均+/-标准差非整倍性为 64.4+/-8.4%。健康对照组的平均+/-标准差 CCT 测量值为 514+/-27 微米（P=0.002）；平均+/-标准差细胞计数为 2649+/-363 个细胞/mm²（P=0.48）；平均+/-标准差 CoV 为 27.6+/-5.5（P<0.001）；平均+/-标准差非整倍性为 61.1+/-8.6%（P=0.04）。
本研究评估表明，肌强直性营养不良症患者较厚的角膜与内皮细胞数量或外观无关。
