Suzuki Shigenobu, Suzuki Yasuyuki, Iwase Aiko, Araie Makoto
Division of Ophthalmology, National Cancer Center Hospital, Tokyo, Japan.
Ophthalmology. 2005 Aug;112(8):1327-36. doi: 10.1016/j.ophtha.2005.03.022.
To investigate the distribution of central corneal thickness (CCT) and factors correlating with CCT in a large-scale population of ophthalmologically normal Japanese persons.
Cross-sectional study.
Participants (n = 7313; 2848 men and 4465 women) were selected as an ophthalmologically normal Japanese sample using the following exclusion criteria: abnormal results suggestive of any eye diseases revealed on slit-lamp examination, fundus photography, or visual field test using frequency doubling technology; corrected visual acuity worse than 0.7; and contact lens wear within 1 week. All study participants were identified from The Eye Disease Screening Service in Tajimi city during the period from September, 2000, through October, 2001.
The CCT was measured by SP-2000P specular microscopy (Topcon, Tokyo, Japan). Age, gender, body mass index, systolic blood pressure, laterality, refraction, corneal radius, and intraocular pressure (IOP) data were collected from the records.
The CCT value and its correlating factors.
Average CCT in this ophthalmologically normal Japanese population was 517.5+/-29.8 microm (mean+/-standard deviation; n = 7313) and was greater in men (521.5+/-30.3 microm) than in women (514.4+/-29.0 microm). The CCT positively correlated with IOP and corneal radius and negatively correlated with refraction, although the correlation was weak. Intraocular pressure measured with a Goldmann applanation tonometer positively correlated with CCT, and the correction was not affected by age (corrected IOP = IOP reading -0.012 [CCT (microm) - 520]).
Using optical pachymetry, CCT in normal Japanese persons was defined as 517.5+/-29.8 microm. Men had greater CCT measurements than women. The CCT measurements positively correlated with IOP and corneal radius and negatively correlated with age and refraction in men. Intraocular pressure positively correlated with CCT, regardless of age.
调查在大量眼科检查正常的日本人中中央角膜厚度（CCT）的分布情况以及与CCT相关的因素。
横断面研究。
参与者（n = 7313；男性2848名，女性4465名）被选为眼科检查正常的日本样本，采用以下排除标准：裂隙灯检查、眼底照相或使用频率加倍技术的视野检查显示有任何眼部疾病的异常结果；矫正视力低于0.7；以及在1周内佩戴过隐形眼镜。所有研究参与者均来自2000年9月至2001年10月期间的多治见市眼病筛查服务中心。
使用SP - 2000P镜面显微镜（日本东京拓普康公司）测量CCT。从记录中收集年龄、性别、体重指数、收缩压、眼别、屈光、角膜半径和眼压（IOP）数据。
CCT值及其相关因素。
在这个眼科检查正常的日本人群中，平均CCT为517.5±29.8微米（平均值±标准差；n = 7313），男性（521.5±30.3微米）高于女性（514.4±29.0微米）。CCT与IOP和角膜半径呈正相关，与屈光呈负相关，尽管相关性较弱。用Goldmann压平眼压计测量的眼压与CCT呈正相关，且这种相关性不受年龄影响（矫正眼压 = 眼压读数 - 0.012×[CCT（微米） - 520]）。
使用光学测厚法，正常日本人的CCT定义为517.5±29.8微米。男性的CCT测量值高于女性。男性的CCT测量值与IOP和角膜半径呈正相关，与年龄和屈光呈负相关。眼压与CCT呈正相关，与年龄无关。
