强直性肌营养不良患者的眼压和角膜生物力学特性

Intraocular pressure and corneal biomechanical properties in patients with myotonic dystrophy.

作者信息

Rosa Nicola, Lanza Michele, Borrelli Maria, Palladino Alberto, Di Gregorio M Grazia, Politano Luisa

机构信息

Centro Grandi Apparecchiature, 2nd University of Naples, Naples, Italy.

出版信息

Ophthalmology. 2009 Feb;116(2):231-4. doi: 10.1016/j.ophtha.2008.09.001. Epub 2008 Nov 18.

DOI:10.1016/j.ophtha.2008.09.001

PMID:19019447

Abstract

PURPOSE

To compare intraocular pressure (IOP) between patients with myotonic dystrophy (DM1) and normal subjects, taking into account corneal characteristics. To determine whether lower IOP measurements in patients with DM1 are due to thinner corneas.

DESIGN

Comparative case series.

PARTICIPANTS

Fifty-three eyes of patients with DM1 and 53 eyes of normal age- and sex-matched subjects.

METHODS

Corneal biomechanical properties and corneal compensated intraocular pressure (IOPcc) measured with the Ocular Response Analyzer (Reichert Inc., Depew, NY), central corneal thickness measured with the Oculus Pentacam (Oculus, Wetzlar, Germany), and IOP were evaluated in patients with DM1 and compared with age- and sex-matched healthy subjects.

MAIN OUTCOME MEASUREMENTS

Goldmann applanation tonometry, central corneal thickness, corneal hysteresis (CH), corneal resistance factor (CRF), and IOPcc.

RESULTS

Compared with the healthy subjects, patients with DM1 showed lower IOP (12.4+/-3.6 mm Hg vs. 14.9+/-3.4 mmHg) (P<0.01) and IOPcc (12.7+/-4.5 vs. 15.9+/-3.5) (P<0.01), and thicker cornea (575.9+/-35.02 mum vs. 556.3+/-33.2 microm) (P<0.01), but no significant changes in CH (P = 0.03) and CRF (P = 0.37).

CONCLUSIONS

Lower IOP in patients with DM1 is not related to differences in central corneal thickness or corneal biomechanical properties.

FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

摘要

目的

比较强直性肌营养不良（DM1）患者与正常受试者的眼压（IOP），同时考虑角膜特征。确定DM1患者较低的眼压测量值是否归因于角膜较薄。

设计

比较性病例系列研究。

参与者

53例DM1患者的眼睛以及53例年龄和性别匹配的正常受试者的眼睛。

方法

使用眼反应分析仪（Reichert公司，纽约州迪皮尤）测量角膜生物力学特性和角膜补偿眼压（IOPcc），使用Oculus Pentacam（德国韦茨拉尔的Oculus公司）测量中央角膜厚度，并对DM1患者的眼压进行评估，并与年龄和性别匹配的健康受试者进行比较。

主要观察指标

Goldmann压平眼压测量法、中央角膜厚度、角膜滞后（CH）、角膜阻力因子（CRF）和IOPcc。

结果

与健康受试者相比，DM1患者的眼压较低（12.4±3.6 mmHg对14.9±3.4 mmHg）（P<0.01）和IOPcc较低（12.7±4.5对15.9±3.5）（P<0.01），角膜较厚（575.9±35.02 µm对556.3±33.2 µm）（P<0.01），但CH（P = 0.03）和CRF（P = 0.37）无显著变化。