Division of Organic Chemistry-I, Natural Product Laboratory, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
Bioorg Med Chem Lett. 2010 Jan 15;20(2):549-53. doi: 10.1016/j.bmcl.2009.11.103. Epub 2009 Nov 26.
Bioactivity-directed investigation of root extract of Derris scandens has led to the isolation and characterization of a new benzil derivative (11), along with ten known compounds (1-10). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. The insect antifeedant activity and growth inhibitory studies of these compounds were investigated against castor semilooper pest, Achaea janata using a no-choice laboratory bioassay. Several of the isolates displayed potent feeding deterrence and were also toxic or caused developmental abnormalities following topical administration. The new compound, derrisdione A was moderately active with an antifeedant index of 58.6+/-1.7% at 10microg/cm(3) against A. janata.
从鸡血藤根提取物中进行生物活性导向分离，得到了一个新的二苯甲酮衍生物（11），以及另外 10 个已知化合物（1-10）。它们的结构是通过广泛的光谱（IR、MS、1D 和 2D NMR）数据分析和与文献数据的比较来确定的。对这些化合物进行了抗蓖麻尺蠖害虫 Achaea janata 的拒食活性和生长抑制研究，采用无选择实验室生物测定法。几种分离物表现出强烈的拒食作用，并且在局部给药后也有毒性或引起发育异常。新化合物 derrisdione A 具有中等活性，在 10μg/cm(3)浓度下对 A. janata 的拒食指数为 58.6+/-1.7%。
