Department of Neurosurgery, School of Medicine, Kinki University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589 8511, Japan.
J Clin Neurosci. 2010 Jan;17(1):118-21. doi: 10.1016/j.jocn.2009.06.033. Epub 2009 Dec 6.
We aimed to demonstrate the effectiveness of fluorescence-guided surgery of metastatic brain tumors using fluorescein sodium. The study comprised 38 patients with metastatic brain tumors who underwent tumor resection after intravenous injection of fluorescein sodium. The local recurrence rate was investigated in 36 of the 38 patients, and compared for patients who had undergone surgery only and surgery plus whole-brain radiotherapy (WBRT). In 31 of 36 patients, the tumors had been completely resected using fluorescence-guided surgery. Postoperative WBRT was not performed in 20 of the 31 patients who underwent gross total resection. Although the recurrence rate for these 20 patients was 20%, compared to 9.1% for the 11 patients who also underwent postoperative WBRT, the difference was not statistically significant. Use of fluorescein sodium in metastatic brain tumor surgery may reduce the rate of local recurrence, and thus help improve the quality of life for these patients.
我们旨在展示使用荧光素钠的脑转移瘤荧光引导手术的有效性。该研究纳入了 38 例接受静脉注射荧光素钠后行肿瘤切除术的脑转移瘤患者。对 38 例患者中的 36 例进行了局部复发率的研究，并对仅行手术和手术加全脑放疗（WBRT）的患者进行了比较。在 36 例患者中的 31 例中，使用荧光引导手术完全切除了肿瘤。在 31 例接受大体全切除的患者中，有 20 例未行术后 WBRT。虽然这 20 例患者的复发率为 20%，但与接受术后 WBRT 的 11 例患者的 9.1%相比，差异无统计学意义。在脑转移瘤手术中使用荧光素钠可能会降低局部复发率，从而有助于提高这些患者的生活质量。
