Department of Neonatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Pediatrics. 2010 Jan;125(1):e24-8. doi: 10.1542/peds.2009-0990. Epub 2009 Dec 7.
The rate of weight gain in preterm infants who are exposed to music seems to improve. A potential mechanism could be increased metabolic efficiency; therefore, we conducted this study to test the hypothesis that music by Mozart reduces resting energy expenditure (REE) in growing healthy preterm infants. DESIGN. A prospective, randomized clinical trial with crossover was conducted in 20 healthy, appropriate-weight-for-gestational-age, gavage-fed preterm infants. Infants were randomly assigned to be exposed to a 30-minute period of Mozart music or no music on 2 consecutive days. Metabolic measurements were performed by indirect calorimetry.
REE was similar during the first 10-minute period of both randomization groups. During the next 10-minute period, infants who were exposed to music had a significantly lower REE than when not exposed to music (P = .028). This was also true during the third 10-minute period (P = .03). Thus, on average, the effect size of music on REE is a reduction of approximately 10% to 13% from baseline, an effect obtained within 10 to 30 minutes.
Exposure to Mozart music significantly lowers REE in healthy preterm infants. We speculate that this effect of music on REE might explain, in part, the improved weight gain that results from this "Mozart effect."
接触音乐的早产儿体重增加速度似乎有所提高。其潜在机制可能是代谢效率增加；因此，我们进行了这项研究，以验证莫扎特音乐可降低生长中健康早产儿静息能量消耗（REE）这一假设。
在 20 名健康、适合胎龄、管饲喂养的早产儿中进行了一项前瞻性、随机临床试验，采用交叉设计。婴儿被随机分配在连续两天接受 30 分钟莫扎特音乐或无音乐暴露。通过间接测热法进行代谢测量。
在随机分组的前 10 分钟，REE 相似。在接下来的 10 分钟内，暴露于音乐的婴儿的 REE 明显低于未暴露于音乐的婴儿（P =.028）。在第三个 10 分钟期间也是如此（P =.03）。因此，音乐对 REE 的平均影响大小是基线时降低约 10%至 13%，这一效果在 10 至 30 分钟内获得。
接触莫扎特音乐可显著降低健康早产儿的 REE。我们推测，音乐对 REE 的这种影响部分解释了接触音乐对体重增加的影响。
