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A Series of spontaneous tumors in Mice with Observations on the Influence of Heredity on the Frequency of their Occurrence.

作者信息

Tyzzer E E

出版信息

J Med Res. 1909 Oct;21(3):479-518.13.

PMID:19971929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2099039/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/57b149a7afb4/jmedres00078-0205-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/2c5b788a70a5/jmedres00078-0210-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/c27e13a55715/jmedres00078-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/16a05f25708d/jmedres00078-0206-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/badd8b8c1032/jmedres00078-0206-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/3f288d6c2fac/jmedres00078-0206-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/5ebffcffa86e/jmedres00078-0206-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/aec73f29e392/jmedres00078-0209-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/fb5ac06164ce/jmedres00078-0209-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/ff4f02344c7b/jmedres00078-0209-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/ac76f7be266f/jmedres00078-0209-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/8d4a8ee505e4/jmedres00078-0209-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/2018857a5850/jmedres00078-0208-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/9d87cb113255/jmedres00078-0208-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/0572219a0fd8/jmedres00078-0208-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/e9104a865795/jmedres00078-0208-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/4d3a4fb95859/jmedres00078-0208-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/b8dca36a725f/jmedres00078-0207-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/953c961ba4aa/jmedres00078-0207-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/421e7dd08273/jmedres00078-0207-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/db807d965f56/jmedres00078-0207-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/f976ef364229/jmedres00078-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/c73b695ded0c/jmedres00078-0204-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/3158b5ece085/jmedres00078-0204-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/a9376c0a6f5e/jmedres00078-0205-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/e7ff432b140b/jmedres00078-0205-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/689ee203004c/jmedres00078-0205-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/57b149a7afb4/jmedres00078-0205-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/2c5b788a70a5/jmedres00078-0210-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/c27e13a55715/jmedres00078-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/16a05f25708d/jmedres00078-0206-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/badd8b8c1032/jmedres00078-0206-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/3f288d6c2fac/jmedres00078-0206-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/5ebffcffa86e/jmedres00078-0206-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/aec73f29e392/jmedres00078-0209-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/fb5ac06164ce/jmedres00078-0209-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/ff4f02344c7b/jmedres00078-0209-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/ac76f7be266f/jmedres00078-0209-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/8d4a8ee505e4/jmedres00078-0209-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/2018857a5850/jmedres00078-0208-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/9d87cb113255/jmedres00078-0208-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/0572219a0fd8/jmedres00078-0208-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/e9104a865795/jmedres00078-0208-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/4d3a4fb95859/jmedres00078-0208-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/b8dca36a725f/jmedres00078-0207-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/953c961ba4aa/jmedres00078-0207-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/421e7dd08273/jmedres00078-0207-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/db807d965f56/jmedres00078-0207-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/f976ef364229/jmedres00078-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/c73b695ded0c/jmedres00078-0204-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/3158b5ece085/jmedres00078-0204-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/a9376c0a6f5e/jmedres00078-0205-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/e7ff432b140b/jmedres00078-0205-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/689ee203004c/jmedres00078-0205-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b75/2099039/57b149a7afb4/jmedres00078-0205-d.jpg

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2
Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research.无论是否发生突变，直接导致肿瘤状态（即细胞永生化和自主性）的因素仍然未知，这应该是我们研究中的优先事项。
J Cancer. 2022 Jul 4;13(9):2810-2843. doi: 10.7150/jca.72628. eCollection 2022.
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Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology.
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J Cancer. 2020 Mar 4;11(10):2887-2920. doi: 10.7150/jca.41324. eCollection 2020.
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The neoplastic potentialities of mouse embryo tissues; lung adenomas in baby mice as result of prenatal exposure to urethane.小鼠胚胎组织的肿瘤形成潜能；幼鼠因产前接触氨基甲酸乙酯而产生的肺腺瘤。
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