Porfirio B, Smeets D, Beckers L, Caporossi D, Tedeschi B, Vernole P, Joenje H, Nicoletti B, Dallapiccola B
Department of Public Health and Cell Biology, 2nd University of Rome, Italy.
Hum Genet. 1991 Jan;86(3):256-60. doi: 10.1007/BF00202404.
The distribution of chromosome breaks induced by the antitumor drug cis-diamine-dichloroplatinum (II) in lymphocyte cultures from Fanconi anemia patients was analyzed. Breakpoints occurred nonrandomly over an arbitrarily defined human karyotype of 319 bands. These bands were classified according to either their banding pattern or their fragile site status (whether or not a fragile site of a given type is located at a chromosomal band). A significant involvement of G-light and fragile site bands was detected. The preferential occurrence of breaks at fragile site bands was limited to common fragile site bands (essentially of the aphidicolin-type).
分析了抗肿瘤药物顺二氯二氨铂（II）在范可尼贫血患者淋巴细胞培养物中诱导的染色体断裂分布情况。断点在任意定义的319条带的人类核型上非随机出现。这些带根据其带型或其脆性位点状态（给定类型的脆性位点是否位于染色体带上）进行分类。检测到G浅带和脆性位点带显著受累。脆性位点带处断裂的优先发生仅限于常见脆性位点带（主要是阿非科林型）。
