Poll E H, Arwert F, Joenje H, Wanamarta A H
Hum Genet. 1985;71(3):206-10. doi: 10.1007/BF00284574.
Fanconi anaemia (FA) lymphocytes were tested for their susceptibility to chromosomal breakage by cis-diamminedichloroplatinum (II) [cis-Pt(II)] and its stereoisomer trans-diamminedichloroplatinum (II) [trans-Pt(II)]. Unlike trans-Pt(II), which is a rather inefficient clastogen, cis-Pt(II) is very efficient in inducing chromosomal breakage in FA cells at concentrations that hardly affect control cells. As both cis-Pt(II) and trans-Pt(II) are capable of inducing DNA interstrand crosslinks but only cis-Pt(II) can induce DNA intrastrand crosslinks, this result suggests that FA cells may be specifically sensitive to the intrastrand type of DNA crosslink.
对范可尼贫血（FA）淋巴细胞进行了测试，以检测其对顺二氯二氨铂（II）[顺铂（II）]及其立体异构体反二氯二氨铂（II）[反铂（II）]导致染色体断裂的易感性。与反铂（II）这种效率较低的致断裂剂不同，顺铂（II）在几乎不影响对照细胞的浓度下就能非常有效地诱导FA细胞发生染色体断裂。由于顺铂（II）和反铂（II）都能够诱导DNA链间交联，但只有顺铂（II）能诱导DNA链内交联，这一结果表明FA细胞可能对DNA链内交联类型具有特异性敏感性。
