人淋巴细胞染色体中MspI诱导断裂的分布及其与常见脆性位点的关系。
The distribution of MspI-induced breaks in human lymphocyte chromosomes and its relationship to common fragile sites.
作者信息
Porfirio B, Tedeschi B, Vernole P, Caporossi D, Nicoletti B
机构信息
Department of Public Health and Cell Biology, 2nd University of Rome, Italy.
出版信息
Mutat Res. 1989 Aug;213(2):117-24. doi: 10.1016/0027-5107(89)90142-5.
PMID:2474762
Abstract
The restriction endonuclease MspI (cleavage site C/CGG) induces chromosomal breaks in human lymphocytes. The breakpoints are distributed non-randomly along the chromosomes and the pattern of MspI-induced breakage depends on the recovery time (20 h or 6 h). Chromosomal bands preferentially involved in breakage are likely to coincide with bands where common fragile sites are located.
摘要
限制性内切酶MspI（切割位点为C/CGG）可诱导人类淋巴细胞中的染色体断裂。断点沿染色体呈非随机分布，且MspI诱导的断裂模式取决于恢复时间（20小时或6小时）。优先参与断裂的染色体带可能与常见脆性位点所在的带重合。
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