Asplund R, Aberg H
County Hospital, Strömsund, Sweden.
J Intern Med. 1991 Feb;229(2):131-4. doi: 10.1111/j.1365-2796.1991.tb00320.x.
The secretion of antidiuretic hormone (ADH) and the serum osmolality were measured at 4-h intervals throughout a 24-h period in 69 healthy elderly volunteers. In male subjects the concentrations of plasma ADH were always twofold higher than in female subjects. The normal diurnal rhythm, with increased ADH secretion during the night, was not seen in this group of elderly subjects, with the exception of elderly men who did not urinate during the night, in whom a substantial increase in plasma ADH levels occurred. In as many as 25% of all the ADH measurements performed (n = 455) ADH was not detectable by the method used. The lack of a definite diurnal rhythm in most of the elderly subjects could to some extent explain the increased diuresis during the night in the elderly.
在69名健康老年志愿者中，于24小时内每隔4小时测量一次抗利尿激素（ADH）分泌量和血清渗透压。男性受试者血浆ADH浓度始终比女性受试者高两倍。除了夜间不排尿的老年男性血浆ADH水平大幅升高外，该老年人群体未观察到正常的昼夜节律，即夜间ADH分泌增加。在所进行的全部ADH测量（n = 455）中，多达25% 的测量结果无法通过所用方法检测到ADH。大多数老年受试者缺乏明确的昼夜节律在一定程度上可以解释老年人夜间尿量增加的现象。
