西咪替丁与香豆素治疗肾细胞癌：一项初步研究。
Cimetidine and coumarin therapy of renal cell carcinoma. A pilot study.
作者信息
Kokron O, Maca S, Gasser G, Schmidt P R
机构信息
5th Medical Department, Krankenhaus Lainz, Austria.
出版信息
Oncology. 1991;48(2):102-6. doi: 10.1159/000226905.
Thirty-eight patients with metastatic renal-cell carcinoma (RCC) and 1 patient with a second primary RCC were treated with coumarin and cimetidine. Patients received 400 mg cimetidine p.o. daily and after 1 week 100 mg coumarin p.o. daily in addition until tumour progression. Two complete remission (30 and 50+ months) and 3 partial remissions (14, 13.8 months) could be achieved. Problems regarding possibly spontaneous regressions and comparable results of other treatment in RCC are discussed.
38例转移性肾细胞癌（RCC）患者和1例第二原发性RCC患者接受了香豆素和西咪替丁治疗。患者每天口服400mg西咪替丁，1周后加服每天口服100mg香豆素，直至肿瘤进展。可实现2例完全缓解（分别为30个月和50多个月）和3例部分缓解（分别为14个月、13.8个月）。讨论了关于RCC可能的自发消退以及其他治疗的可比结果的问题。
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