Nolte H, Pedersen L, Mouridsen H T
Anticancer Res. 1987 May-Jun;7(3 Pt B):449-50.
An immunostimulant therapy with coumarin and cimetidine was evaluated in 17 patients with advanced malignant melanoma. Induction therapy with coumarin 100 mg daily was given for 8 weeks, after which cimetidine 1000 mg daily was added. No patients had been previously treated with cytotoxic drugs. All patients had good performance status. Sixteen patients experienced progressive disease, and only one patient showed no change lasting for 30 weeks. It is concluded that treatment with this schedule of coumarin and cimetidine is without effect in advanced malignant melanoma.
对17例晚期恶性黑色素瘤患者进行了香豆素与西咪替丁免疫刺激疗法的评估。给予患者每日100毫克香豆素进行诱导治疗，为期8周，之后添加每日1000毫克西咪替丁。所有患者此前均未接受过细胞毒性药物治疗。所有患者的身体状况良好。16例患者病情进展，只有1例患者病情无变化，持续了30周。结论是，这种香豆素与西咪替丁治疗方案对晚期恶性黑色素瘤无效。
