Yang J N, Murphy A D, Madsen E L, Zagzebski J A, Gilchrist K W, Frank G R, Macdonald M C, Millard C A, Faraggi A, Jaramillo C A
Department of Medical Physics, University of Wisconsin-Madison 53706.
Ultrason Imaging. 1991 Jan;13(1):91-109. doi: 10.1177/016173469101300105.
A method has been developed for mapping density and ultrasonic speed in 1 mm thick slices of soft tissue with a resolution of about 1 mm. Tests using phantom sections have verified the accuracy and resolution of the ultrasonic speed maps. The method has been applied to breast tissues of three patients including tumors and surrounding tissue. Fixing a specimen in 5% formaldehyde did not change the degree of local variation in ultrasonic speeds, and raised mean speeds by less than 0.8%. The densities with fixing remained almost unchanged at low tissue densities (0.93 g/cm3), but rose 1.5% for higher tissue density (greater than 1.00 g/cm3).
已开发出一种方法，用于绘制1毫米厚软组织切片中的密度和超声速度图，分辨率约为1毫米。使用模拟切片进行的测试验证了超声速度图的准确性和分辨率。该方法已应用于三名患者的乳腺组织，包括肿瘤及周围组织。将标本固定在5%的甲醛中不会改变超声速度的局部变化程度，且平均速度升高不到0.8%。在低组织密度（0.93克/立方厘米）下，固定后的密度几乎保持不变，但在高组织密度（大于1.00克/立方厘米）时密度升高了1.5%。
