Pittet J F, Morel D R, Hemsen A, Gunning K, Lacroix J S, Suter P M, Lundberg J M
Department of Anesthesiology, University Hospital of Geneva, Switzerland.
Ann Surg. 1991 Mar;213(3):261-4. doi: 10.1097/00000658-199103000-00014.
Plasma immunoreactive endothelin-1 concentrations were determined by radioimmunoassay in 11 septic patients during the first 24 hours after the development of the sepsis syndrome in 15 nonseptic postoperative patients studied 24 hours after open heart surgery and in 14 healthy volunteers. Mean endothelin-1 plasma concentrations were significantly (p less than 0.001) increased in septic patients (19.9 +/- 2.2 pg/mL, mean +/- standard error) compared to concentrations found in postoperative cardiac patients (11.9 +/- 0.7 pg/mL) or in healthy volunteers (6.1 +/- 0.3 pg/mL). In septic patients elevated plasma concentrations of endothelin-1 were inversely correlated with cardiac index (r = -0.80, p less than 0.005) and positively correlated the severity of illness as documented by APACHE II score (r = 0.74, p less than 0.01) and plasma creatinine levels (r = 0.80, p less than 0.005). No such correlations were found in postoperative cardiac patients. These results indicate that endothelin-1 concentrations are correlated with the severity of illness and depression of cardiac output in patients with sepsis.
采用放射免疫分析法测定了11例脓毒症患者在脓毒症综合征发生后的最初24小时内、15例非脓毒症心脏术后患者术后24小时以及14名健康志愿者的血浆免疫反应性内皮素-1浓度。与心脏术后患者（11.9±0.7 pg/mL）或健康志愿者（6.1±0.3 pg/mL）相比，脓毒症患者的内皮素-1血浆平均浓度显著升高（p<0.001）（19.9±2.2 pg/mL，平均值±标准误）。在脓毒症患者中，内皮素-1血浆浓度升高与心脏指数呈负相关（r = -0.80，p<0.005），与APACHE II评分所记录的疾病严重程度呈正相关（r = 0.74，p<0.01），与血浆肌酐水平呈正相关（r = 0.80，p<0.005）。在心脏术后患者中未发现此类相关性。这些结果表明，脓毒症患者体内内皮素-1浓度与疾病严重程度及心输出量降低相关。
