人类S100α和β亚基基因的结构与染色体定位
Structure and chromosome assignment of human S100 alpha and beta subunit genes.
作者信息
Morii K, Tanaka R, Takahashi Y, Minoshima S, Fukuyama R, Shimizu N, Kuwano R
机构信息
Research Laboratory for Molecular Genetics, Niigata University, Japan.
出版信息
Biochem Biophys Res Commun. 1991 Feb 28;175(1):185-91. doi: 10.1016/s0006-291x(05)81218-5.
The human S-100 alpha and beta subunit genes were isolated from human genomic DNA library. The restriction endonuclease mapping and DNA sequencing analysis revealed that both subunit genes consisted of three exons and two introns. Two Ca2(+)-binding domains were independently encoded by exon 2 and exon 3. Spot-blot hybridization analysis with flow-sorted chromosomes showed that human alpha and beta subunit genes were assigned to chromosome 1 and chromosome 21, respectively.
人S-100α和β亚基基因是从人基因组DNA文库中分离出来的。限制性内切酶图谱分析和DNA测序分析表明，这两个亚基基因均由三个外显子和两个内含子组成。两个Ca2(+)结合结构域分别由外显子2和外显子3独立编码。用流式细胞仪分选的染色体进行斑点杂交分析表明，人α和β亚基基因分别定位于第1号染色体和第21号染色体。
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