Gallagher J P, Shinnick-Gallagher P
Science. 1977 Nov 25;198(4319):851-2. doi: 10.1126/science.199943.
Intracellular iontophoresis of either adenosine 3',5'-monophosphate or guanosine 3',5'-monophosphate produces a membrane depolarization and an increased membrane conductance in sympathetic ganglion cells of the rat superior cervical ganglion. Since adenosine 3',5'-monophosphate did not cause a membrane hyperpolarization, it is difficult to assign it a second messenger role in the mediation of the slow inhibitory postsynaptic potential. However, these results do not rule out the possibility that the cyclic nucleotides, at the intracellular concentrations attained in these experiments, participate in cellular processes that contribute to conductance changes which result in depolarization of the ganglion cell membrane.
在大鼠颈上神经节的交感神经节细胞中，3',5'-环磷酸腺苷或3',5'-环磷酸鸟苷的细胞内离子电渗作用会产生膜去极化并增加膜电导。由于3',5'-环磷酸腺苷不会引起膜超极化，因此很难赋予其在介导缓慢抑制性突触后电位中第二信使的作用。然而，这些结果并不排除在这些实验中达到的细胞内浓度下，环核苷酸参与细胞过程，这些过程导致电导变化，进而引起神经节细胞膜去极化的可能性。
