二丁酰环磷腺苷3',5'-单磷酸酯和茶碱对牛蛙交感神经节细胞的作用。
Effects of dibutyryl cyclic adenosine 3',5'-monophosphate and theophylline on the bullfrog sympathetic ganglion cells.
作者信息
Akasu T, Koketsu K
出版信息
Br J Pharmacol. 1977 Jul;60(3):331-6. doi: 10.1111/j.1476-5381.1977.tb07504.x.
1 Effects of dibutyryl cyclic adenosine 3',5'-monophosphate (dibutyryl cyclic AMP) and theophylline on bullfrog sympathetic ganglion cells were examined in order to test the hypothesis that cyclic AMP is essential for the generation of slow inhibitory postsynaptic potentials (i.p.s.ps) in these cells. 2 In the absence or presence of theophylline, dibutyryl cyclic AMP did not hyperpolarize but rather tended to depolarize ganglia that were hyperpolarized by adrenaline. 3 Theophylline augmented neither the P-potential (slow i.p.s.p.) nor adrenaline-induced hyperpolarization. 4 Thus, cyclic AMP does not seem to be essential for the generation of the slow i.p.s.p., at least in amphibian sympathetic ganglion cells.
- 为了验证环磷酸腺苷（cAMP）对于牛蛙交感神经节细胞中慢抑制性突触后电位（i.p.s.ps）的产生至关重要这一假说，研究了二丁酰环磷腺苷（二丁酰cAMP）和茶碱对牛蛙交感神经节细胞的影响。2. 在不存在或存在茶碱的情况下，二丁酰环磷腺苷不会使被肾上腺素超极化的神经节超极化，反而倾向于使其去极化。3. 茶碱既不增强P电位（慢i.p.s.p.），也不增强肾上腺素诱导的超极化。4. 因此，至少在两栖动物交感神经节细胞中，环磷酸腺苷似乎对于慢i.p.s.p.的产生并非必不可少。
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