二丁酰环磷腺苷3',5'-单磷酸酯和茶碱对牛蛙交感神经节细胞的作用。
Effects of dibutyryl cyclic adenosine 3',5'-monophosphate and theophylline on the bullfrog sympathetic ganglion cells.
作者信息
Akasu T, Koketsu K
出版信息
Br J Pharmacol. 1977 Jul;60(3):331-6. doi: 10.1111/j.1476-5381.1977.tb07504.x.
Abstract
1 Effects of dibutyryl cyclic adenosine 3',5'-monophosphate (dibutyryl cyclic AMP) and theophylline on bullfrog sympathetic ganglion cells were examined in order to test the hypothesis that cyclic AMP is essential for the generation of slow inhibitory postsynaptic potentials (i.p.s.ps) in these cells. 2 In the absence or presence of theophylline, dibutyryl cyclic AMP did not hyperpolarize but rather tended to depolarize ganglia that were hyperpolarized by adrenaline. 3 Theophylline augmented neither the P-potential (slow i.p.s.p.) nor adrenaline-induced hyperpolarization. 4 Thus, cyclic AMP does not seem to be essential for the generation of the slow i.p.s.p., at least in amphibian sympathetic ganglion cells.
摘要
- 为了验证环磷酸腺苷（cAMP）对于牛蛙交感神经节细胞中慢抑制性突触后电位（i.p.s.ps）的产生至关重要这一假说，研究了二丁酰环磷腺苷（二丁酰cAMP）和茶碱对牛蛙交感神经节细胞的影响。2. 在不存在或存在茶碱的情况下，二丁酰环磷腺苷不会使被肾上腺素超极化的神经节超极化，反而倾向于使其去极化。3. 茶碱既不增强P电位（慢i.p.s.p.），也不增强肾上腺素诱导的超极化。4. 因此，至少在两栖动物交感神经节细胞中，环磷酸腺苷似乎对于慢i.p.s.p.的产生并非必不可少。
相似文献
1
Effects of dibutyryl cyclic adenosine 3',5'-monophosphate and theophylline on the bullfrog sympathetic ganglion cells.二丁酰环磷腺苷3',5'-单磷酸酯和茶碱对牛蛙交感神经节细胞的作用。
Br J Pharmacol. 1977 Jul;60(3):331-6. doi: 10.1111/j.1476-5381.1977.tb07504.x.
2
The mechanism of the inhibitory action of adrenaline on transmitter release in bullfrog sympathetic ganglia: independence of cyclic AMP and calcium ions.肾上腺素对牛蛙交感神经节中递质释放的抑制作用机制：环磷酸腺苷与钙离子的独立性
Br J Pharmacol. 1985 Feb;84(2):435-43. doi: 10.1111/j.1476-5381.1985.tb12928.x.
3
Synaptic potentials in sympathetic ganglia: are they mediated by cyclic nucleotides?交感神经节中的突触电位：它们是由环核苷酸介导的吗？
Science. 1978 Jun 2;200(4345):1079-81. doi: 10.1126/science.206964.
4
Adrenaline and the electrogenic sodium pump in Rana catesbeiana sympathetic ganglion cells.肾上腺素与牛蛙交感神经节细胞中的生电钠泵
Experientia. 1976 Jan 15;32(1):57-9. doi: 10.1007/BF01932621.
5
Effects of theophylline and dibutyryl cyclic adenosine monophosphate on the membrane potential of mouse pancreatic beta-cells.茶碱和二丁酰环磷酸腺苷对小鼠胰腺β细胞膜电位的影响。
J Physiol. 1984 Jun;351:595-612. doi: 10.1113/jphysiol.1984.sp015265.
6
Relation between catecholamine-induced cyclic AMP changes and hyperpolarization in isolated rat sympathetic ganglia.儿茶酚胺诱导的环磷酸腺苷变化与离体大鼠交感神经节超极化之间的关系。
J Physiol. 1979 May;290(2):441-51. doi: 10.1113/jphysiol.1979.sp012782.
7
Cyclic nucleotides injected intracellularly into rat superior cervical ganglion cells.向大鼠颈上神经节细胞内注射环核苷酸。
Science. 1977 Nov 25;198(4319):851-2. doi: 10.1126/science.199943.
8
Cyclic GMP modulates the intensity of post-tetanic potentiation in bullfrog sympathetic ganglia.环磷酸鸟苷调节牛蛙交感神经节中强直后增强的强度。
Neuropharmacology. 1976 Jan;15(1):11-6. doi: 10.1016/0028-3908(76)90091-5.
9
Effects of theophylline and N6,O2-dibutyryl adenosine 3':5'-monophosphate on sympathetic ganglionic transmission in rats.
J Pharmacol Exp Ther. 1978 Apr;205(1):91-103.
10
Long-term potentiation of transmitter release induced by adrenaline in bull-frog sympathetic ganglia.肾上腺素诱导牛蛙交感神经节递质释放的长期增强作用。
J Physiol. 1986 May;374:515-30. doi: 10.1113/jphysiol.1986.sp016095.
引用本文的文献
1
Cyclic adenosine 3',5'-monophosphate and beta-effects in rat isolated superior cervical ganglia.环磷酸腺苷与大鼠离体颈上神经节中的β效应
Br J Pharmacol. 1983 Jun;79(2):441-9. doi: 10.1111/j.1476-5381.1983.tb11017.x.
2
Beta-adrenergic modulation of the Na+-K+ pump in frog skeletal muscles.青蛙骨骼肌中钠钾泵的β-肾上腺素能调节
Pflugers Arch. 1985 Sep;405(1):24-8. doi: 10.1007/BF00591093.
3
Relation between catecholamine-induced cyclic AMP changes and hyperpolarization in isolated rat sympathetic ganglia.儿茶酚胺诱导的环磷酸腺苷变化与离体大鼠交感神经节超极化之间的关系。
J Physiol. 1979 May;290(2):441-51. doi: 10.1113/jphysiol.1979.sp012782.
本文引用的文献
1
The Effect of Caffeine on Radiocalcium Movement in Frog Sartorius.咖啡因对蛙直肌中放射性钙运动的影响。
J Gen Physiol. 1961 May 1;44(5):845-58. doi: 10.1085/jgp.44.5.845.
2
Electrical properties and activities of single sympathetic neurons in frogs.青蛙单个交感神经元的电特性与活动
J Cell Comp Physiol. 1960 Feb;55:15-30. doi: 10.1002/jcp.1030550104.
3
Origin and blockade of the synaptic responses of curarized sympathetic ganglia.箭毒处理的交感神经节突触反应的起源与阻断
J Physiol. 1961 Aug;157(3):484-503. doi: 10.1113/jphysiol.1961.sp006738.
4
Origin of ganglionic inhibitory postsynaptic potential.神经节抑制性突触后电位的起源
Life Sci. 1967 Oct 1;6(19):2049-55. doi: 10.1016/0024-3205(67)90223-8.
5
Characteristics of the slow inhibitory postsynaptic potential of bullfrog sympathetic ganglion cells.
Life Sci. 1967 Sep 1;6(17):1827-36. doi: 10.1016/0024-3205(67)90211-1.
6
The relationship between caffeine contracture of intact muscle and the effect of caffeine on reticulum.完整肌肉的咖啡因挛缩与咖啡因对肌浆网的作用之间的关系
J Gen Physiol. 1968 Nov;52(5):750-9. doi: 10.1085/jgp.52.5.750.
7
On the electrogenic sodium pump in mammalian non-myelinated nerve fibres and its activation by various external cations.关于哺乳动物无髓神经纤维中的生电钠泵及其被各种外部阳离子激活的情况。
J Physiol. 1968 May;196(1):183-221. doi: 10.1113/jphysiol.1968.sp008502.
8
Cholinergic receptors at sympathetic preganglionic nerve terminals.交感神经节前神经末梢处的胆碱能受体。
J Physiol. 1968 May;196(2):293-310. doi: 10.1113/jphysiol.1968.sp008508.
9
Resting and action potentials recorded by the sucrose-gap method in the superior cervical ganglion of the rabbit.用蔗糖间隙法在兔颈上神经节记录的静息电位和动作电位。
J Physiol. 1968 Mar;195(1):39-53. doi: 10.1113/jphysiol.1968.sp008445.
10
Actions of noradrenaline and acetylcholine on sympathetic ganglion cells.去甲肾上腺素和乙酰胆碱对交感神经节细胞的作用。
J Physiol. 1970 Jun;208(2):353-72. doi: 10.1113/jphysiol.1970.sp009125.
Zotero 插件