Lechner K, Niessner H, Thaler E
Semin Thromb Hemost. 1977 Summer;4(1):40-56. doi: 10.1055/s-0028-1087127.
The decreased capacity of the liver to synthesize proteins is the main cause of decreased blood levels of clotting factors II, V, VII, IX, X and of antithrombin III in patients with liver disease. Therefore, determination of the activity or concentration of these coagulation proteins is a useful test of liver function and guide to prognosis, provided that other mechanisms which may influence the blood level are carefully considered. Clotting factor assays have an only limited value for the differential diagnosis in liver disease.
肝脏合成蛋白质能力下降是肝病患者血液中凝血因子II、V、VII、IX、X及抗凝血酶III水平降低的主要原因。因此，测定这些凝血蛋白的活性或浓度是一项有用的肝功能检测及预后指标，前提是要仔细考虑其他可能影响血液水平的机制。凝血因子检测在肝病鉴别诊断中的价值有限。
