CDRH/NIBIB Laboratory for the Assessment of Medical Imaging Systems, Division of Imaging and Applied Mathematics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993-0002, USA.
Med Phys. 2009 Nov;36(11):4944-56. doi: 10.1118/1.3233683.
MANTIS is a Monte Carlo code developed for the detailed simulation of columnar CsI scintillator screens in x-ray imaging systems. Validation of this code is needed to provide a reliable and valuable tool for system optimization and accurate reconstructions for a variety of x-ray applications. Whereas previous validation efforts have focused on matching of summary statistics, in this work the authors examine the complete point response function (PRF) of the detector system in addition to relative light output values.
Relative light output values and high-resolution PRFs have been experimentally measured with a custom setup. A corresponding set of simulated light output values and PRFs have also been produced, where detailed knowledge of the experimental setup and CsI:Tl screen structures are accounted for in the simulations. Four different screens were investigated with different thicknesses, column tilt angles, and substrate types. A quantitative comparison between the experimental and simulated PRFs was performed for four different incidence angles (0 degrees, 15 degrees, 30 degrees, and 45 degrees) and two different x-ray spectra (40 and 70 kVp). The figure of merit (FOM) used measures the normalized differences between the simulated and experimental data averaged over a region of interest.
Experimental relative light output values ranged from 1.456 to 1.650 and were in approximate agreement for aluminum substrates, but poor agreement for graphite substrates. The FOMs for all screen types, incidence angles, and energies ranged from 0.1929 to 0.4775. To put these FOMs in context, the same FOM was computed for 2D symmetric Gaussians fit to the same experimental data. These FOMs ranged from 0.2068 to 0.8029. Our analysis demonstrates that MANTIS reproduces experimental PRFs with higher accuracy than a symmetric 2D Gaussian fit to the experimental data in the majority of cases. Examination of the spatial distribution of differences between the PRFs shows that the main reason for errors between MANTIS and the experimental data is that MANTIS-generated PRFs are sharper than the experimental PRFs.
The experimental validation of MANTIS performed in this study demonstrates that MANTIS is able to reliably predict experimental PRFs, especially for thinner screens, and can reproduce the highly asymmetric shape seen in the experimental data. As a result, optimizations and reconstructions carried out using MANTIS should yield results indicative of actual detector performance. Better characterization of screen properties is necessary to reconcile the simulated light output values with experimental data.
MANTIS 是一个用于详细模拟 X 射线成像系统中柱状 CsI 闪烁体屏幕的蒙特卡罗代码。需要验证该代码,为各种 X 射线应用的系统优化和准确重建提供可靠且有价值的工具。虽然之前的验证工作侧重于汇总统计数据的匹配,但在这项工作中,作者除了相对光输出值之外,还检查了探测器系统的完整点响应函数 (PRF)。
使用定制的设置实验测量了相对光输出值和高分辨率 PRF。还产生了相应的一组模拟光输出值和 PRF,其中在模拟中考虑了实验设置和 CsI:Tl 屏幕结构的详细知识。研究了四种不同厚度、柱状倾斜角度和基底类型的屏幕。对于四个不同的入射角(0 度、15 度、30 度和 45 度)和两个不同的 X 射线光谱(40 和 70 kVp),对实验和模拟 PRF 进行了定量比较。使用的符合度 (FOM) 指标衡量了在感兴趣区域内模拟数据与实验数据之间的归一化差异。
实验相对光输出值范围为 1.456 到 1.650,对于铝基底大致一致,但对于石墨基底则不一致。所有屏幕类型、入射角和能量的 FOM 范围为 0.1929 到 0.4775。为了将这些 FOM 放在上下文中,对同一实验数据进行了 2D 对称高斯拟合,计算了相同的 FOM。这些 FOM 的范围为 0.2068 到 0.8029。我们的分析表明,在大多数情况下,MANTIS 比 2D 对称高斯拟合实验数据更准确地再现实验 PRF。对 PRF 之间差异的空间分布进行检查表明,MANTIS 与实验数据之间产生误差的主要原因是 MANTIS 生成的 PRF 比实验 PRF 更尖锐。
本研究对 MANTIS 进行的实验验证表明,MANTIS 能够可靠地预测实验 PRF,特别是对于较薄的屏幕,并且可以再现实验数据中看到的高度非对称形状。因此,使用 MANTIS 进行的优化和重建应产生指示实际探测器性能的结果。需要更好地描述屏幕特性,以使模拟光输出值与实验数据相协调。