用于定量评价动态对比增强 MRI 的动态病变体模的开发和特性研究。
Development and characterization of a dynamic lesion phantom for the quantitative evaluation of dynamic contrast-enhanced MRI.
机构信息
Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA.
出版信息
Med Phys. 2011 Oct;38(10):5601-11. doi: 10.1118/1.3633911.
PURPOSE
To develop a dynamic lesion phantom that is capable of producing physiological kinetic curves representative of those seen in human dynamic contrast-enhanced MRI (DCE-MRI) data. The objective of this phantom is to provide a platform for the quantitative comparison of DCE-MRI protocols to aid in the standardization and optimization of breast DCE-MRI.
METHODS
The dynamic lesion consists of a hollow, plastic mold with inlet and outlet tubes to allow flow of a contrast agent solution through the lesion over time. Border shape of the lesion can be controlled using the lesion mold production method. The configuration of the inlet and outlet tubes was determined using fluid transfer simulations. The total fluid flow rate was determined using x-ray images of the lesion for four different flow rates (0.25, 0.5, 1.0, and 1.5 ml/s) to evaluate the resultant kinetic curve shape and homogeneity of the contrast agent distribution in the dynamic lesion. High spatial and temporal resolution x-ray measurements were used to estimate the true kinetic curve behavior in the dynamic lesion for benign and malignant example curves. DCE-MRI example data were acquired of the dynamic phantom using a clinical protocol.
RESULTS
The optimal inlet and outlet tube configuration for the lesion molds was two inlet molds separated by 30° and a single outlet tube directly between the two inlet tubes. X-ray measurements indicated that 1.0 ml/s was an appropriate total fluid flow rate and provided truth for comparison with MRI data of kinetic curves representative of benign and malignant lesions. DCE-MRI data demonstrated the ability of the phantom to produce realistic kinetic curves.
CONCLUSIONS
The authors have constructed a dynamic lesion phantom, demonstrated its ability to produce physiological kinetic curves, and provided estimations of its true kinetic curve behavior. This lesion phantom provides a tool for the quantitative evaluation of DCE-MRI protocols, which may lead to improved discrimination of breast cancer lesions.
目的
开发一种能够产生与人体动态对比增强 MRI（DCE-MRI）数据中所见相似的生理动力学曲线的动态病变体模。该体模的目的是为 DCE-MRI 协议的定量比较提供一个平台，以帮助标准化和优化乳腺 DCE-MRI。
方法
动态病变由一个中空的塑料模具组成，带有入口和出口管，以便随着时间的推移通过病变输送对比剂溶液。病变的边界形状可以通过病变模具制作方法来控制。入口和出口管的配置是通过流体转移模拟确定的。使用病变的 X 射线图像确定总流体流量，对于四个不同的流速（0.25、0.5、1.0 和 1.5 ml/s），评估所得动力学曲线形状和对比剂在动态病变中的分布均匀性。使用高空间和时间分辨率的 X 射线测量来估计动态病变中真实的动力学曲线行为，使用良性和恶性示例曲线进行估计。使用临床协议对动态体模采集 DCE-MRI 示例数据。
结果
病变模具的最佳入口和出口管配置是两个入口模具之间间隔 30°，以及一个直接位于两个入口管之间的单个出口管。X 射线测量表明，1.0 ml/s 是合适的总流体流量，并为与代表良性和恶性病变的 MRI 数据的动力学曲线进行比较提供了真实值。DCE-MRI 数据表明，该体模能够产生逼真的动力学曲线。
结论
作者构建了一种动态病变体模，证明了其产生生理动力学曲线的能力，并提供了对其真实动力学曲线行为的估计。这种病变体模为 DCE-MRI 协议的定量评估提供了一种工具，可能有助于提高乳腺癌病变的鉴别能力。
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