Taran T T, Guly M F, Mykhajlovskyj V O, Dvornykova P D, Fanak M M, Vorobjov N A
Ukr Biokhim Zh. 1977 Sep-Oct;49(5):64-9.
Healing of the bone injury in rabbits was studied as affected by carbostimulin and its mixture with vitamin D3. Some biochemical indexes: the content of sialic acids, calcium and citric acid in blood serum of the animals, intensity of 14C incorporation from NaH14CO3 into the regenerated bone tissue and its proteins as well as histological studies, data, evidence for a positive effect of the mentioned preparations on the bone substance regeneration in the animals under experiment. So. the content of sialic acids in blood serum normalizes on the 10th day after the operation mostly in the animals which were administered the mixture of the preparations and in which the most pronounced hypercalcemia is observed. Incorporation of 14C from NaH14CO3 into the regenerated tissue and its proteins is most intensive in the same animals.
研究了卡波司他汀及其与维生素D3的混合物对兔骨损伤愈合的影响。一些生化指标:动物血清中唾液酸、钙和柠檬酸的含量,NaH14CO3中14C掺入再生骨组织及其蛋白质的强度以及组织学研究,数据表明上述制剂对实验动物的骨质再生有积极作用。因此,在术后第10天,大多在给予制剂混合物且观察到最明显高钙血症的动物中,血清中唾液酸含量恢复正常。在相同动物中,NaH14CO3中14C掺入再生组织及其蛋白质的情况最为强烈。