Department of Dermatology, Venereology and Allergology, Medical University, Wrocław, Poland.
Acta Derm Venereol. 2009 Nov;89(6):601-3. doi: 10.2340/00015555-0749.
Hidradenitis suppurativa (HS) is a recurrent, debilitating suppurative skin disease. Nowadays the major challenge is the choice of optimal treatment. Many conservative therapies seem to have only a supportive character and do not prevent progression of the disease. Early surgical intervention with complete excision of the involved areas is still considered to be the most efficient therapy, but anti-tumour necrosis factor (TNF)-alpha agents may offer a possible non-surgical treatment. The aim of this study was to determine the serum concentration of TNF-alpha and its probable alterations during the disease process in patients with HS. Analysis of TNF-alpha serum concentration in 54 individuals with HS revealed significantly higher levels than in the sera of healthy controls (p = 0.006). To the best of our knowledge, this is the first report of increased TNF-alpha serum concentration in patients with HS.
化脓性汗腺炎（HS）是一种反复发作、使人虚弱的化脓性皮肤病。目前的主要挑战是选择最佳治疗方法。许多保守治疗似乎只有支持作用，不能阻止疾病的进展。早期进行完整切除受累区域的手术干预仍被认为是最有效的治疗方法，但抗肿瘤坏死因子（TNF）-α 药物可能提供一种非手术治疗方法。本研究旨在确定化脓性汗腺炎患者血清 TNF-α浓度及其在疾病过程中的可能变化。对 54 名化脓性汗腺炎患者的 TNF-α 血清浓度分析显示，其浓度明显高于健康对照组（p = 0.006）。据我们所知，这是化脓性汗腺炎患者 TNF-α 血清浓度升高的首次报告。
